Inhibition of chemical carcinogenesis by Psoralea corylifolia seeds

被引：25

作者：

Latha, PG ^{[1
]}

Panikkar, KR ^{[1
]}

机构：

[1] Trop Bot Garden & Res Inst, Ethnomed & Ethnopharmacol Div, Trivandrum 695562, Kerala, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1999年 / 68卷 / 1-3期

关键词：

Psoralea corylifolia; chemical carcinogenesis inhibition; croton oil;

D O I：

10.1016/S0378-8741(99)00062-8

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Psoralea corylifolia L. (Fabaceae) seeds are extensively used in Ayurvedic medicine. Topical application of 100 mg/kg body weight of the active fraction (AF) of P. corylifolia seeds inhibited the growth and delayed the onset of papilloma formation in mice, initiated with 7,12-dimethyl benz(a) anthracene and promoted using croton oil. The AF at the same dose, when administered orally, inhibited the growth of subcutaneously injected 20-methylcholanthrene (MCA) - induced soft tissue fibrosarcomas significantly. The AF has been shown by gas chromatography analysis to be composed of a mixture of glycerides of fatty acids. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：295 / 298

页数：4

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