Trafficking of endosomal Toll-like receptors

被引：172

作者：

Lee, Bettina L. ^{[1
]}

Barton, Gregory M. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

TRENDS IN CELL BIOLOGY | 2014年 / 24卷 / 06期

基金：

美国国家卫生研究院;

关键词：

innate immunity; type I interferon; UNC93B1; AP complex; autoimmunity; NUCLEIC-ACID RECOGNITION; SINGLE-STRANDED RNA; BACTERIAL-DNA; INTRACELLULAR COMPARTMENTS; VIRAL RECOGNITION; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; DENDRITIC CELLS; MURINE MODEL; CPG MOTIFS;

D O I：

10.1016/j.tcb.2013.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Over the past decade we have learned much about nucleic acid recognition by the innate immune system and in particular by Toll-like receptors (TLRs). These receptors localize to endosomal compartments where they are poised to recognize microbial nucleic acids. Multiple regulatory mechanisms function to limit responses to self DNA or RNA, and breakdowns in these mechanisms can contribute to autoimmune or inflammatory disorders. In this review we discuss our current understanding of the cell biology of TLRs involved in nucleic acid recognition and how localization and trafficking of these receptors regulates their function.

引用

页码：360 / 369

页数：10

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