A pair of diastereoisomeric steroidal saponins from cytotoxic extracts of Tupistra chinensis rhizomes

被引：33

作者：

Zou, Kun ^{[1
]}

Wang, Junzhi

Du, Ming

Li, Qing

Tu, Guangzhong

机构：

[1] China Three Gorges Univ, Coll Chem & Life Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang 443002, Peoples R China

[2] Beijing Inst Microchem, Beijing 100094, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 10期

关键词：

Tupistra chinesis; steroidal saponin; cytotoxicity; folk medicine;

D O I：

10.1248/cpb.54.1440

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A pair of diastereoisomeric steroidal saponins were obtained from the saponin fraction (SF) of methanol extracts from Tupistra chinensis rhizomes, collected in Shennongjia Forest District, China. Based on the chemical and spectroscopic evidences, their structures were determined as shown in Fig. 1. The sample SF displayed marked inhibitory action in vitro towards HeLa and HL-60 cancer cell lines at 10 mu g/ml by MTT method.

引用

页码：1440 / 1442

页数：3

共 18 条

[1] Dependence of 1H NMR chemical shifts of geminal protons of glycosyloxy methylene (H2-26) on the orientation of the 27-methyl group of furostane-type steroidal saponins [J].

Agrawal, PK .

MAGNETIC RESONANCE IN CHEMISTRY, 2004, 42 (11) :990-993

[2] Furostanol saponins and quercetin glycosides from the leaves of Helleborus viridis L. [J].

Braca, A ;

Prieto, JM ;

De Tommasi, N ;

Tomè, F ;

Morelli, I .

PHYTOCHEMISTRY, 2004, 65 (21) :2921-2928

[3] Chemical composition of shallot (Allium ascalonicum Hort) [J].

Fattorusso, E ;

Iorizzi, M ;

Lanzotti, V ;

Taglialatela-Scafati, O .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (20) :5686-5690

[4]

HUANG L, 2003, J CHINA 3 GORGES U, V25, P562

[5]

MARKER RE, 1941, J AM CHEM SOC, V65, P1199

[6]

Murakami T, 2000, CHEM PHARM BULL, V48, P994

[7] New flavans, spirostanol sapogenins, and a pregnane genin from Tupistra chinensis and their cytotoxicity [J].

Pan, WB ;

Chang, FR ;

Wei, LM ;

Wu, YC .

JOURNAL OF NATURAL PRODUCTS, 2003, 66 (02) :161-168

[8]

Pan WB, 2000, CHEM PHARM BULL, V48, P1350, DOI 10.1248/cpb.48.1350

[9] Tupichigenin A, a new steroidal sapogenin from Tupistra chinensis [J].

Pan, WB ;

Chang, FR ;

Wu, YC .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (06) :861-863

[10]

PEREIRA BDS, 1999, PHYTOCHEMISTRY, V51, P931

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