A highly stereoselective synthesis of optically active trisubstituted 1,2-ethylenediamines:: The first example of Grignard addition to N-diphenylphosphinoyl ketimines derived from amino acids
The efficient synthesis of optically active trisubstituted 1,2-ethylenediamines is described. Addition of aryl and/or alkyl Grignard reagents to a-amino N-diphenylphosphinoyl ketimines derived from a-amino acids was demonstrated to afford the desired trisubstituted 1,2-ethylenediamines in good yields and with high diastereoselectivities. Subsequent removal of the diphenyphosphinoyl group from the adduct was smoothly accomplished in reasonable yield without racemization under newly developed reductive conditions.
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Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R ChinaChinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R China
Wang, Y
Guo, H
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Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R ChinaChinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R China
Guo, H
Ding, KL
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Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R ChinaChinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R China
机构:
Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R ChinaChinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R China
Wang, Y
Guo, H
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机构:
Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R ChinaChinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R China
Guo, H
Ding, KL
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机构:
Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R ChinaChinese Acad Sci, Shanghai Inst Organ Chem, Lab Organometall Chem, Shanghai 200032, Peoples R China