Antioxidant properties of omeprazole

被引：65

作者：

Lapenna, D

deGioia, S

Ciofani, G

Festi, D

Cuccurullo, F

机构：

[1] Istituto di Fisiopatologia Medica, Univ. degli Studi G. D'Annunzio, Fac. di Medicina e Chirurgia, 66100 Chieti, Via dei Vestini

来源：

FEBS LETTERS | 1996年 / 382卷 / 1-2期

关键词：

omeprazole; hypochlorous acid; iron; copper; oxidative stress; antioxidant;

D O I：

10.1016/0014-5793(96)00155-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Potential antioxidant properties of therapeutically achievable concentrations of the protonated, active form of omeprazole (OM) were investigated in vitro at specific acidic pH values to mimic intragastric conditions in the clinical setting. We found that OM is a powerful scavenger of hypochlorous acid (HOCl) even at a drug concentration of 10 mu M at pH of 5.3 or 3.5. This effect is also evident in the presence of the physiological HOCI scavenger ascorbate. Moreover, 10 and 50 mu M OM inhibit significantly both iron-and copper-driven oxidant damage at pH 5.3 and 3.5, respectively. Since oxidative stress is involved the gastric injury of peptic ulcer and gastritis, it may be hypothesized that some therapeutical effects of OM could also be related to its antioxidant properties.

引用

页码：189 / 192

页数：4

共 39 条

[1] THE IRON-BINDING AND HYDROXYL RADICAL SCAVENGING ACTION OF ANTI-INFLAMMATORY DRUGS [J].

ARUOMA, OI ;

HALLIWELL, B .

XENOBIOTICA, 1988, 18 (04) :459-470

[2] EFFECT OF INTRAVENOUS AND ORAL OMEPRAZOLE ON 24-HOUR INTRAGASTRIC ACIDITY IN DUODENAL-ULCER PATIENTS [J].

CEDERBERG, C ;

THOMSON, ABR ;

MAHACHAI, V ;

WESTIN, JA ;

KIRDEIKIS, P ;

FISHER, D ;

ZUK, L ;

MARRIAGE, B .

GASTROENTEROLOGY, 1992, 103 (03) :913-918

[3] A SITE-SPECIFIC MECHANISM FOR FREE-RADICAL INDUCED BIOLOGICAL DAMAGE - THE ESSENTIAL ROLE OF REDOX-ACTIVE TRANSITION-METALS [J].

CHEVION, M .

FREE RADICAL BIOLOGY AND MEDICINE, 1988, 5 (01) :27-37

[4] PROTECTION AGAINST FREE RADICAL-INDUCED AND TRANSITION METAL-MEDIATED DAMAGE - THE USE OF PULL AND PUSH MECHANISMS [J].

CHEVION, M .

FREE RADICAL RESEARCH COMMUNICATIONS, 1991, 12-3 :691-696

[5] MUCOSAL REACTIVE OXYGEN METABOLITE PRODUCTION IN DUODENAL-ULCER DISEASE [J].

DAVIES, GR ;

SIMMONDS, NJ ;

STEVENS, TRJ ;

GRANDISON, A ;

BLAKE, DR ;

RAMPTON, DS .

GUT, 1992, 33 (11) :1467-1472

[6]

FARINATI F, 1993, EUR J GASTROEN HEPAT, V5, pS9

[7] SUPEROXIDE-DEPENDENT FORMATION OF HYDROXYL RADICALS IN THE PRESENCE OF IRON SALTS - WHAT IS THE PHYSIOLOGICAL IRON CHELATOR [J].

FLITTER, W ;

ROWLEY, DA ;

HALLIWELL, B .

FEBS LETTERS, 1983, 158 (02) :310-312

[8]

Glantz S A., 1987, Primer of Biostatistics

[9]

Gutteridge J. M. C., 1989, FREE RADICALS BIOL M

[10] COPPER SALT-DEPENDENT HYDROXYL RADICAL FORMATION - DAMAGE TO PROTEINS ACTING AS ANTI-OXIDANT [J].

GUTTERIDGE, JMC ;

WILKINS, S .

BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 759 (1-2) :38-41

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