Antioxidant properties of omeprazole

被引:65
作者
Lapenna, D
deGioia, S
Ciofani, G
Festi, D
Cuccurullo, F
机构
[1] Istituto di Fisiopatologia Medica, Univ. degli Studi G. D'Annunzio, Fac. di Medicina e Chirurgia, 66100 Chieti, Via dei Vestini
关键词
omeprazole; hypochlorous acid; iron; copper; oxidative stress; antioxidant;
D O I
10.1016/0014-5793(96)00155-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Potential antioxidant properties of therapeutically achievable concentrations of the protonated, active form of omeprazole (OM) were investigated in vitro at specific acidic pH values to mimic intragastric conditions in the clinical setting. We found that OM is a powerful scavenger of hypochlorous acid (HOCl) even at a drug concentration of 10 mu M at pH of 5.3 or 3.5. This effect is also evident in the presence of the physiological HOCI scavenger ascorbate. Moreover, 10 and 50 mu M OM inhibit significantly both iron-and copper-driven oxidant damage at pH 5.3 and 3.5, respectively. Since oxidative stress is involved the gastric injury of peptic ulcer and gastritis, it may be hypothesized that some therapeutical effects of OM could also be related to its antioxidant properties.
引用
收藏
页码:189 / 192
页数:4
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