Whispering gallery mode carousel - a photonic mechanism for enhanced nanoparticle detection in biosensing

被引：188

作者：

Arnold, S. ^{[1
]}

Keng, D. ^{[1
]}

Shopova, S. I. ^{[1
]}

Holler, S. ^{[2
]}

Zurawsky, W. ^{[1
]}

Vollmer, F. ^{[3
]}

机构：

[1] NYU, Polytech Inst, Microparticle Photophys Lab, Brooklyn, NY 11201 USA

[2] Novawave Technol, Redwood Shores, CA 94065 USA

[3] Harvard Univ, Rowland Inst, Cambridge, MA 02142 USA

来源：

OPTICS EXPRESS | 2009年 / 17卷 / 08期

基金：

美国国家科学基金会;

关键词：

LABEL-FREE; SHIFT;

D O I：

10.1364/OE.17.006230

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Individual nanoparticles in aqueous solution are observed to be attracted to and orbit within the evanescent sensing ring of a Whispering Gallery Mode micro-sensor with only microwatts of driving power. This Carousel trap, caused by attractive optical gradient forces, interfacial interactions, and the circulating momentum flux, considerably enhances the rate of transport to the sensing region, thereby overcoming limitations posed by diffusion on such small area detectors. Resonance frequency fluctuations, caused by the radial Brownian motion of the nanoparticle, reveal the radial trapping potential and the nanoparticle size. Since the attractive forces draw particles to the highest evanescent intensity at the surface, binding steps are found to be uniform. (C) 2009 Optical Society of America

引用

页码：6230 / 6238

页数：9

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