Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse

被引：26

作者：

Xiong, Qing ^{[1
,4
]}

Jiao, Yan ^{[1
]}

Hasty, Karen A. ^{[1
]}

Canale, S. Terry ^{[1
]}

Stuart, John M. ^{[2
]}

Beamer, Wesley G. ^{[3
]}

Deng, Hong-Wen ^{[5
,6
]}

Baylink, David ^{[7
]}

Gu, Weikuan ^{[1
]}

机构：

[1] Univ Tennessee, Ctr Hlth Sci, Dept Orthopaed Surg, Campbell Clin & Pathol, Memphis, TN 38163 USA

[2] Univ Tennessee, Ctr Hlth Sci, Dept Med, Memphis, TN 38163 USA

[3] Jackson Lab, Bar Harbor, ME 04609 USA

[4] Southwest Univ, Dept Comp Sci & Technol, Chongqing 400715, Peoples R China

[5] Univ Missouri, Dept Orthoped Surg, Kansas City, MO 64110 USA

[6] Univ Missouri, Dept Basic Med Sci, Kansas City, MO 64110 USA

[7] Loma Linda Univ, Dept Med, Loma Linda, CA 92350 USA

来源：

GENOMICS | 2009年 / 93卷 / 05期

关键词：

BMD; QTL; Gene; Polymorphism; Mouse; SINGLE NUCLEOTIDE POLYMORPHISM; POSTMENOPAUSAL JAPANESE WOMEN; RECEPTOR-RELATED PROTEIN-5; DIFFERENTIATION IN-VITRO; CAST/EIJ INBRED MICE; GROWTH-FACTOR-I; OSTEOBLAST DIFFERENTIATION; LUMBAR SPINE; FRACTURE RISK; KOREAN WOMEN;

D O I：

10.1016/j.ygeno.2008.12.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

his is all in silico analysis of data available from genome-wide scans. Through analysis of QTL, genes and polymorphisms that regulate BMD, we identified 82 BMD QTL 191 BMD-associated (BMDA) genes, and 83 genes containing known BMD-associated polymorphisms (BMDAP). The Catalogue of all BMDA/BMDAP genes and relevant literatures are provided. In total, there are Substantially more BMDA/BMDAP genes in regions of the genome where QTL have been identified than in non-QTL. regions. Among 191 BMDA genes and 83 BMDAP genes, 133 and 58 are localized in QTL regions, respectively. The difference was still noticeable for the chromosome distribution of these genes between QTL and non-QTL legions. These results have allowed us to generate an integrative profile of QTL, genes, polymorphisms that determine BMD. These data Could facilitate more rapid and comprehensive identification Of Causal genes underlying the determination of BMD ill mouse and provide new insights into how BMD is regulated in humans. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：401 / 414

页数：14

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