Mitochondrial Ca2+ Transport: Mechanisms, Molecular Structures, and Role in Cells

被引：136

作者：

Belosludtsev, K. N. ^{[1
,2
]}

Dubinin, M. V. ^{[2
]}

Belosludtseva, N. V. ^{[1
]}

Mironova, G. D. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia

[2] Mari State Univ, Yoshkar Ola 424000, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2019年 / 84卷 / 06期

基金：

俄罗斯科学基金会; 俄罗斯基础研究基金会;

关键词：

mitochondria; Ca2+ transport; MCU; NCLX; MPT pore; mitochondrial pore; lipid pore; PERMEABILITY TRANSITION PORE; CALCIUM EFFLUX MECHANISM; ENDOPLASMIC-RETICULUM; ESSENTIAL COMPONENT; CYCLOSPORINE-A; PALMITIC ACID; ATP SYNTHASE; NA+/CA2+ EXCHANGER; LIVER-MITOCHONDRIA; RUTHENIUM RED;

D O I：

10.1134/S0006297919060026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Mitochondria are among the most important cell organelles involved in the regulation of intracellular calcium homeostasis. During the last decade, a number of molecular structures responsible for the mitochondrial calcium transport have been identified including the mitochondrial Ca2+ uniporter (MCU), Na+/Ca2+ exchanger (NCLX), and Ca2+/H+ antiporter (Letm1). The review summarizes the data on the structure, regulation, and physiological role of such structures. The pathophysiological mechanism of Ca2+ transport through the cyclosporine A-sensitive mitochondrial permeability transition pore is discussed. An alternative mechanism for the mitochondrial pore opening, namely, formation of the lipid pore induced by saturated fatty acids, and its role in Ca2+ transport are described in detail.

引用

页码：593 / 607

页数：15

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