Gas chromatographic enantiomer separation on a chiral self-associating selector

被引：15

作者：

Betschinger, F ^{[1
]}

Libman, J ^{[1
]}

Shanzer, A ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT ORGAN CHEM,IL-76100 REHOVOT,ISRAEL

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 746卷 / 01期

关键词：

enantiomer separation; chiral stationary phases; GC; amino acids; hydroxy acids;

D O I：

10.1016/0021-9673(96)00308-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel chiral stationary phase bearing a tripodal selector is described. In gas chromatography this phase exhibits high enantioselectivity towards derivatized amino acids and moderate capability for the enantiomer separation of derivatized hydroxy acids. Due to a C-3 symmetric arrangement of three N-acyl-valine-tert-butyl amide groups the tripodal selector adopts a hydrogen bonding network involving inter- and intrastrand hydrogen bonds. Thus a conformationally constrained structure is formed which is stable up to 150 degrees C.

引用

页码：53 / 62

页数：10

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