Assessment of response to preoperative chemotherapy in patients with stage II and III breast cancer: the value of MRI

被引：8

作者：

Cocquyt, VF ^{[1
]}

Villeirs, GM ^{[1
]}

Blondeel, PN ^{[1
]}

Depypere, HT ^{[1
]}

Mortier, MM ^{[1
]}

Serreyn, RF ^{[1
]}

Van den Broecke, R ^{[1
]}

Van Belle, SJP ^{[1
]}

机构：

[1] Ghent Univ Hosp, Dept Med Oncol, B-9000 Ghent, Belgium

来源：

BREAST | 2002年 / 11卷 / 04期

关键词：

D O I：

10.1054/brst.2002.0450

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The response to preoperative chemotherapy in breast cancer was assessed by magnetic resonance imaging (MRI), and compared to the histological and clinical findings. Forty-two patients with stage II and III breast carcinoma were evaluated prospectively prior to and after preoperative chemotherapy by MRI, clinical and histological examination. Radiological response was assessed using the MRI parameters: total tumor volume (TTV), maximum enhancement index (MEI) and their product (TTV*MEI). A significant reduction in all MRI parameters was observed after chemotherapy. Overall clinical and radiological response rates were comparable (69% vs 73%). MRI was not useful for the prediction of complete pathologic response. A fair correlation between TTV postchemotherapy and final histological diameter was found. A significant difference of residual TTV for patients undergoing breast conservative surgery vs mastectomy was observed. Conclusion: MRI can demonstrate responses induced by preoperative chemotherapy in breast cancer, but it cannot determine complete pathologic responses. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：306 / 315

页数：10

共 27 条

[1]

Abraham DC, 1996, CANCER, V78, P91, DOI 10.1002/(SICI)1097-0142(19960701)78:1<91::AID-CNCR14>3.0.CO

[2]

2-2

[3] Correlation of three-dimensional magnetic resonance imaging with precise histopathological map concerning carcinoma extension in the breast [J].

Amano, G ;

Ohuchi, N ;

Ishibashi, T ;

Ishida, T ;

Amari, M ;

Satomi, S .

BREAST CANCER RESEARCH AND TREATMENT, 2000, 60 (01) :43-55

[4] Primary chemotherapy in operable breast cancer: Eight-year experience at the Milan Cancer Institute [J].

Bonadonna, G ;

Valagussa, P ;

Brambilla, C ;

Ferrari, L ;

Moliterni, A ;

Terenziani, M ;

Zambetti, M .

JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (01) :93-100

[5] NEW HORIZONS IN THE DIAGNOSIS AND TREATMENT OF BREAST-CANCER USING MAGNETIC-RESONANCE-IMAGING [J].

CROSS, MJ ;

HARMS, SE ;

CHEEK, JH ;

PETERS, GN ;

JONES, RC .

AMERICAN JOURNAL OF SURGERY, 1993, 166 (06) :749-755

[6] Breast cancer measurements with magnetic resonance imaging, ultrasonography, and mammography [J].

Davis, PL ;

Staiger, MJ ;

Harris, KB ;

Ganott, MA ;

Klementaviciene, J ;

McCarthy, KS ;

Tobon, H .

BREAST CANCER RESEARCH AND TREATMENT, 1996, 37 (01) :1-9

[7] Utility of magnetic resonance imaging in the management of breast cancer: Evidence for improved preoperative staging [J].

Esserman, L ;

Hylton, N ;

Yassa, L ;

Barclay, J ;

Frankel, S ;

Sickles, E .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (01) :110-119

[8] MRI phenotype is associated with response to doxorubicin and cyclophosphamide neoadjuvant chemotherapy in stage III breast cancer [J].

Esserman, L ;

Kaplan, E ;

Partridge, S ;

Tripathy, D ;

Rugo, H ;

Park, J ;

Hwang, S ;

Kuerer, H ;

Sudilovsky, D ;

Lu, Y ;

Hylton, N .

ANNALS OF SURGICAL ONCOLOGY, 2001, 8 (06) :549-559

[9] Accuracy of mammography and echography versus clinical palpation in the assessment of response to primary chemotherapy in breast cancer patients with operable disease [J].

Fiorentino, C ;

Berruti, A ;

Bottini, A ;

Bodini, M ;

Brizzi, MP ;

Brunelli, A ;

Marini, U ;

Allevi, G ;

Aguggini, S ;

Tira, A ;

Alquati, P ;

Olivetti, L ;

Dogliotti, L .

BREAST CANCER RESEARCH AND TREATMENT, 2001, 69 (02) :143-151

[10] Breast carcinoma: Effect of preoperative contrast-enhanced MR imaging on the therapeutic approach [J].

Fischer, U ;

Kopka, L ;

Grabbe, E .

RADIOLOGY, 1999, 213 (03) :881-888

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