From grid cells to place cells: A mathematical model

被引:307
作者
Solstad, Trygve
Moser, Edvard I.
Einevoll, Gaute T.
机构
[1] Norwegian Univ Sci & Technol, Ctr Biol Memory, N-7489 Trondheim, Norway
[2] Norwegian Univ Life Sci, Dept Mat Sci & Technol, As, Norway
[3] Norwegian Univ Life Sci, CIGENE, As, Norway
关键词
hippocampus; place cells; entorhinal cortex; grid cells; spatial representation; memory;
D O I
10.1002/hipo.20244
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Anatomical connectivity and recent neurophysiological results imply that grid cells in the medial entorhinal cortex are the principal cortical inputs to place cells in the hippocampus. The authors propose a model in which place fields of hippocampal pyramidal cells are formed by linear summation of appropriately weighted inputs from entorhinal grid cells. Single confined place fields could be formed by summing input from a modest number (10-50) of grid cells with relatively similar grid phases, diverse grid orientations, and a biologically plausible range of grid spacings. When the spatial phase variation in the grid-cell input was higher, multiple, and irregularly spaced firing fields were formed. These observations point to a number of possible constraints in the organization of functional connections between grid cells and place cells. (c) 2006 Wiley-Liss, Inc.
引用
收藏
页码:1026 / 1031
页数:6
相关论文
共 31 条
[21]   Dual phase and rate coding in hippocampal place cells: Theoretical significance and relationship to entorhinal grid cells [J].
O'Keefe, J ;
Burgess, N .
HIPPOCAMPUS, 2005, 15 (07) :853-866
[22]   HIPPOCAMPUS AS A SPATIAL MAP - PRELIMINARY EVIDENCE FROM UNIT ACTIVITY IN FREELY-MOVING RAT [J].
OKEEFE, J ;
DOSTROVS.J .
BRAIN RESEARCH, 1971, 34 (01) :171-&
[23]   Geometric determinants of the place fields of hippocampal neurons [J].
OKeefe, J ;
Burgess, N .
NATURE, 1996, 381 (6581) :425-428
[24]  
QUIRK GJ, 1990, J NEUROSCI, V10, P2008
[25]   Neuron number in the parahippocampal region is preserved in aged rats with spatial learning deficits [J].
Rapp, PR ;
Deroche, PS ;
Mao, Y ;
Burwell, RD .
CEREBRAL CORTEX, 2002, 12 (11) :1171-1179
[26]  
Riley K.F., 2006, Mathematical Methods for Physics and Engineering, P1362, DOI 10.1017/CBO9780511810763
[27]   Conjunctive representation of position, direction, and velocity in entorhinal cortex [J].
Sargolini, F ;
Fyhn, M ;
Hafting, T ;
McNaughton, BL ;
Witter, MP ;
Moser, MB ;
Moser, EI .
SCIENCE, 2006, 312 (5774) :758-762
[28]   Attractor dynamics in the hippocampal representation of the local environment [J].
Wills, TJ ;
Lever, C ;
Cacucci, F ;
Burgess, N ;
O'Keefe, J .
SCIENCE, 2005, 308 (5723) :873-876
[29]   DYNAMICS OF THE HIPPOCAMPAL ENSEMBLE CODE FOR SPACE [J].
WILSON, MA ;
MCNAUGHTON, BL .
SCIENCE, 1993, 261 (5124) :1055-1058
[30]  
Witter M. P., 2004, The rat nervous system, Vthird