Degenerative ataxias: Genetics, pathogenesis and animal models

被引：18

作者：

Kakizuka, A

机构：

来源：

CURRENT OPINION IN NEUROLOGY | 1997年 / 10卷 / 04期

关键词：

D O I：

10.1097/00019052-199708000-00002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

At present, seven inherited neurodegenerative disorders have been identified to be caused by the polyglutamine-coding CAG triplet expansions in the genes responsible. The long stretch of polyglutamines appears to play a key role in the pathogenesis. Disease models, just recently established with cultured cells and animals, will enable elucidation of common disease mechanisms and treatments.

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页码：285 / 290

页数：6

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