Redox-dependent signal transduction

被引：460

作者：

Finkel, T ^{[1
]}

机构：

[1] NHLBI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

FEBS LETTERS | 2000年 / 476卷 / 1-2期

关键词：

signal transduction; redox; peroxide; rac1; NADPH oxidase;

D O I：

10.1016/S0014-5793(00)01669-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide appear to be transiently produced in response to growth factor and cytokine stimulation. A variety of evidence suggests that this ligand-stimulated change in the cellular redox state participates in downstream signal transduction. This review will focus on the effects of ROS on signal transduction pathways, the molecules that regulate intracellular ROS production and the potential protein targets of oxidants. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：52 / 54

页数：3

共 24 条

[1] Epidermal growth factor (EGF)-induced generation of hydrogen peroxide - Role in EGF receptor-mediated tyrosine phosphorylation
Bae, YS
Kang, SW
Seo, MS
Baines, IC
Tekle, E
Chock, PB
Rhee, SG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (01) : 217 - 221
[2] A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1
Bánfi, B
Maturana, A
Jaconi, S
Arnaudeau, S
Laforge, T
Sinha, B
Ligeti, E
Demaurex, N
Krause, KH
[J]. SCIENCE, 2000, 287 (5450) : 138 - 142
[3] Roles of superoxide radical anion in signal transduction mediated by reversible regulation of protein-tyrosine phosphatase 1B
Barrett, WC
DeGnore, JP
Keng, YF
Zhang, ZY
Yim, MB
Chock, PB
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (49) : 34543 - 34546
[4] Assembly of the phagocyte NADPH oxidase: Molecular interaction of oxidase proteins
DeLeo, FR
Quinn, MT
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1996, 60 (06) : 677 - 691
[5] Oxygen radicals and signaling
Finkel, T
[J]. CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (02) : 248 - 253
[6] Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-α signal transduction
Gotoh, Y
Cooper, JA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (28) : 17477 - 17482
[7] ANGIOTENSIN-II STIMULATES NADH AND NADPH OXIDASE ACTIVITY IN CULTURED VASCULAR SMOOTH-MUSCLE CELLS
GRIENDLING, KK
MINIERI, CA
OLLERENSHAW, JD
ALEXANDER, RW
[J]. CIRCULATION RESEARCH, 1994, 74 (06) : 1141 - 1148
[8] NADH/NADPH oxidase and vascular function
Griendling, KK
UshioFukai, M
[J]. TRENDS IN CARDIOVASCULAR MEDICINE, 1997, 7 (08) : 301 - 307
[9] Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts
Irani, K
Xia, Y
Zweier, JL
Sollott, SJ
Der, CJ
Fearon, ER
Sundaresan, M
Finkel, T
GoldschmidtClermont, PJ
[J]. SCIENCE, 1997, 275 (5306) : 1649 - 1652
[10] A Rac1 effector site controlling mitogenesis through superoxide production
Joneson, T
Bar-Sagi, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (29) : 17991 - 17994

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