Redox-dependent signal transduction

被引：460

作者：

Finkel, T ^{[1
]}

机构：

[1] NHLBI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

FEBS LETTERS | 2000年 / 476卷 / 1-2期

关键词：

signal transduction; redox; peroxide; rac1; NADPH oxidase;

D O I：

10.1016/S0014-5793(00)01669-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide appear to be transiently produced in response to growth factor and cytokine stimulation. A variety of evidence suggests that this ligand-stimulated change in the cellular redox state participates in downstream signal transduction. This review will focus on the effects of ROS on signal transduction pathways, the molecules that regulate intracellular ROS production and the potential protein targets of oxidants. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：52 / 54

页数：3

共 24 条

[11] Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change
Kheradmand, F
Werner, E
Tremble, P
Symons, M
Werb, Z
[J]. SCIENCE, 1998, 280 (5365) : 898 - 902
[12] An essential role for free radicals and derived species in signal transduction
Lander, HM
[J]. FASEB JOURNAL, 1997, 11 (02) : 118 - 124
[13] Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor
Lee, SR
Kwon, KS
Kim, SR
Rhee, SG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (25) : 15366 - 15372
[14] Redox signaling: hydrogen peroxide as intracellular messenger
Rhee, SG
[J]. EXPERIMENTAL AND MOLECULAR MEDICINE, 1999, 31 (02) : 53 - 59
[15] A family of novel peroxidases, peroxiredoxins
Rhee, SG
Kang, SW
Netto, LE
Seo, MS
Stadtman, ER
[J]. BIOFACTORS, 1999, 10 (2-3) : 207 - 209
[16] Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
Saitoh, M
Nishitoh, H
Fujii, M
Takeda, K
Tobiume, K
Sawada, Y
Kawabata, M
Miyazono, K
Ichijo, H
[J]. EMBO JOURNAL, 1998, 17 (09) : 2596 - 2606
[17] POTENTIAL ROLE OF HUMAN CYTOMEGALOVIRUS AND P53 INTERACTION IN CORONARY RESTENOSIS
SPEIR, E
MODALI, R
HUANG, ES
LEON, MB
SHAWL, F
FINKEL, T
EPSTEIN, SE
[J]. SCIENCE, 1994, 265 (5170) : 391 - 394
[18] Cell transformation by the superoxide-generating oxidase Mox1
Suh, YA
Arnold, RS
Lassegue, B
Shi, J
Xu, XX
Sorescu, D
Chung, AB
Griendling, KK
Lambeth, JD
[J]. NATURE, 1999, 401 (6748) : 79 - 82
[19] Sulciner DJ, 1996, MOL CELL BIOL, V16, P7115
[20] REQUIREMENT FOR GENERATION OF H2O2 FOR PLATELET-DERIVED GROWTH-FACTOR SIGNAL-TRANSDUCTION
SUNDARESAN, M
YU, ZX
FERRANS, VJ
IRANI, K
FINKEL, T
[J]. SCIENCE, 1995, 270 (5234) : 296 - 299

← 1 2 3 →