Oxygenated Cembranoids from the Cultured and Wild-Type Soft Corals Sinularia flexibilis

被引：43

作者：

Su, Jui-Hsin ^{[1
,3
]}

Lin, Yu-Fang ^{[1
]}

Lu, Yi ^{[1
]}

Yeh, Hsiao-Chien

Wang, Wei-Hsien ^{[1
,4
]}

Fan, Tung-Yung ^{[4
]}

Sheu, Jyh-Horng ^{[1
,2
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[3] Mei Ho Inst Technol, Dept Biol Sci & Technol, Neipu Hsiang 912, Pingtung, Taiwan

[4] Natl Museum Marine Biol & Aquarium, Taiwan Coral Res Ctr, Checheng 944, Pingtung, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2009年 / 57卷 / 11期

关键词：

cembranoid; Sinularia flexibilis; cytotoxicity; TUMOR-CELL-LINES; MARINE-INVERTEBRATES; INDIAN-OCEAN; DITERPENE; COELENTERATA; OCTOCORALLIA; COLLECTION; LACTONES; ASSAY;

D O I：

10.1248/cpb.57.1189

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new cembranoids, flexibilisolide A (1) and flexibilisin A (2), along with one known combranoid 5 have been isolated from the cultured soft coral Sinularia flexibilis. Furthermore, two new cembranoids, flexibilisolide B (3) and flexibilisin B (4), along with two known combranoids (5, 6), have been isolated from the wild-type soft coral S. flexibilis. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis and by comparison of NMR data with those of known compounds. The metabolites 5 and 6 have been shown to exhibit weak cytotoxic activity against MCF-7 cancer cell line.

引用

页码：1189 / 1192

页数：4

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