Targeting BRAF in thyroid cancer

被引：74

作者：

Espinosa, A. V.

Porchia, L.

Ringel, M. D.

机构：

[1] Ohio State Univ, Coll Med, Dept Med, Div Endocrinol, Columbus, OH 43210 USA

[2] Ohio State Univ, Coll Med, Dept Med, Div Oncogen, Columbus, OH 43210 USA

[3] Arthur G James Comprehens Canc Ctr, Columbus, OH USA

来源：

BRITISH JOURNAL OF CANCER | 2007年 / 96卷 / 01期

关键词：

papillary thyroid cancer; RET/PTC oncogene; RAS; POORLY DIFFERENTIATED CARCINOMAS; ENDOTHELIAL GROWTH-FACTOR; GENE-EXPRESSION PROFILES; PAPILLARY CARCINOMAS; RAF/MEK/ERK PATHWAY; MUTATION PREDICTS; HIGH PREVALENCE; SOLID TUMORS; RET/PTC; CELLS;

D O I：

10.1038/sj.bjc.6603520

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activating mutations in the gene encoding BRAF are the most commonly identified oncogenic abnormalities in papillary thyroid cancer. In vitro and in vivo models have demonstrated that overexpression of activated BRAF induces malignant transformation and aggressive tumour behaviour. BRAF and other RAF kinases are frequently activated by other thyroid oncogenes and are important mediators of their biological effects including dedifferentiation and proliferation. Because current therapeutic options for patients with thyroid cancers that are aggressive and/or do not respond to standard therapies are limited, BRAF and its downstream effectors represent attractive therapeutic targets. In this review, data supporting a role for BRAF activation in thyroid cancer development and establishing the potential therapeutic efficacy of BRAF-targeted agents in patients with thyroid cancer will be reviewed.

引用

页码：16 / 20

页数：5

共 43 条

[1] Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas [J].

Adeniran, AJ ;

Zhu, ZW ;

Gandhi, M ;

Steward, DL ;

Fidler, JP ;

Giordano, TJ ;

Biddinger, PW ;

Nikiforov, YE .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2006, 30 (02) :216-222

[2]

Bauer AJ, 2003, ANN CLIN LAB SCI, V33, P192

[3] BRAF mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment [J].

Begum, S ;

Rosenbaum, E ;

Henrique, R ;

Cohen, Y ;

Sidransky, D ;

Westra, WH .

MODERN PATHOLOGY, 2004, 17 (11) :1359-1363

[4] Beyond radioiodine: A review of potential new therapeutic approaches for thyroid cancer [J].

Braga-Basaria, M ;

Ringel, MD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (05) :1947-1960

[5] Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer [J].

Ciampi, R ;

Knauf, JA ;

Kerler, R ;

Gandhi, M ;

Zhu, ZW ;

Nikiforova, MN ;

Rabes, HM ;

Fagin, JA ;

Nikiforov, YE .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (01) :94-101

[6]

CIAMPI R, 2006, ENDOCRINOLOGY 0831

[7] Mutations of the BRAF gene in human cancer [J].

Davies, H ;

Bignell, GR ;

Cox, C ;

Stephens, P ;

Edkins, S ;

Clegg, S ;

Teague, J ;

Woffendin, H ;

Garnett, MJ ;

Bottomley, W ;

Davis, N ;

Dicks, N ;

Ewing, R ;

Floyd, Y ;

Gray, K ;

Hall, S ;

Hawes, R ;

Hughes, J ;

Kosmidou, V ;

Menzies, A ;

Mould, C ;

Parker, A ;

Stevens, C ;

Watt, S ;

Hooper, S ;

Wilson, R ;

Jayatilake, H ;

Gusterson, BA ;

Cooper, C ;

Shipley, J ;

Hargrave, D ;

Pritchard-Jones, K ;

Maitland, N ;

Chenevix-Trench, G ;

Riggins, GJ ;

Bigner, DD ;

Palmieri, G ;

Cossu, A ;

Flanagan, A ;

Nicholson, A ;

Ho, JWC ;

Leung, SY ;

Yuen, ST ;

Weber, BL ;

Siegler, HF ;

Darrow, TL ;

Paterson, H ;

Marais, R ;

Marshall, CJ ;

Wooster, R .

NATURE, 2002, 417 (6892) :949-954

[8] Increasing incidence of thyroid cancer in the United States, 1973-2002 [J].

Davies, L ;

Welch, HG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (18) :2164-2167

[9] Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis [J].

Eisen, T. ;

Ahmad, T. ;

Flaherty, K. T. ;

Gore, M. ;

Kaye, S. ;

Marais, R. ;

Gibbens, I. ;

Hackett, S. ;

James, M. ;

Schuchter, L. M. ;

Nathanson, K. L. ;

Xia, C. ;

Simantov, R. ;

Schwartz, B. ;

Poulin-Costello, M. ;

O'Dwyer, P. J. ;

Ratain, M. J. .

BRITISH JOURNAL OF CANCER, 2006, 95 (05) :581-586

[10] Correlation between B-RAFV600E mutation and clinico-pathologic parameters in papillary thyroid carcinoma:: data from a multicentric Italian study and review of the literature [J].

Fugazzola, L. ;

Puxeddu, E. ;

Avenia, N. ;

Romei, C. ;

Cirello, V. ;

Cavaliere, A. ;

Faviana, P. ;

Mannavola, D. ;

Moretti, S. ;

Rossi, S. ;

Sculli, M. ;

Bottici, V. ;

Beck-Peccoz, P. ;

Pacini, F. ;

Pinchera, A. ;

Santeusanio, F. ;

Elisei, R. .

← 1 2 3 4 5 →