Switching trypanosome coats: what's in the wardrobe?

被引：137

作者：

Taylor, Jesse E.

Rudenko, Gloria

机构：

[1] Univ Oxford, Oxford OX1 3SY, England

[2] Univ Oxford, Dept Stat, Oxford OX1 3TG, England

来源：

TRENDS IN GENETICS | 2006年 / 22卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tig.2006.08.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The African trypanosome Trypanosoma brucei is best known for its extraordinarily sophisticated antigenic variation of a protective variant surface glycoprotein (VSG) coat. T. brucei has > 1000 VSG genes and pseudogenes, of which one is transcribed at a time from one of multiple telomeric VSG expression sites. Switching the active VSG gene can involve DNA rearrangements replacing the old VSG with a new one, or alternatively transcriptional control. The astonishing revelation from the T. brucei genome sequence is that < 7% of the sequenced VSGs seem to have fully functional coding regions. This preponderance of pseudogenes in the VSG gene repertoire will necessitate a rethink of how antigenic variation in African trypanosomes operates.

引用

页码：614 / 620

页数：7

共 48 条

[1] VSG switching in Trypanosoma brucei:: antigenic variation analysed using RNAi in the absence of immune selection [J].

Aitcheson, N ;

Talbot, S ;

Shapiro, J ;

Hughes, K ;

Adkin, C ;

Butt, T ;

Sheader, K ;

Rudenko, G .

MOLECULAR MICROBIOLOGY, 2005, 57 (06) :1608-1622

[2] EARLY EXPRESSION OF A TRYPANOSOMA-BRUCEI VSG GENE DUPLICATED FROM AN INCOMPLETE BASIC COPY [J].

ALINE, RF ;

MYLER, PJ ;

GOBRIGHT, E ;

STUART, KD .

JOURNAL OF EUKARYOTIC MICROBIOLOGY, 1994, 41 (01) :71-78

[3] Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream [J].

Amiguet-Vercher, A ;

Pérez-Morga, D ;

Pays, A ;

Poelvoorde, P ;

Van Xong, H ;

Tebabi, P ;

Vanhamme, L ;

Pays, E .

MOLECULAR MICROBIOLOGY, 2004, 51 (06) :1577-1588

[4] THE IMPORTANCE OF MOSAIC GENES TO TRYPANOSOME SURVIVAL [J].

BARBET, AF ;

KAMPER, SM .

PARASITOLOGY TODAY, 1993, 9 (02) :63-66

[5]

Barry JD, 2005, BIOCHEM SOC T, V33, P986, DOI 10.1042/BST20050986

[6] VSG gene control and infectivity strategy of metacyclic stage Trypanosoma brucei [J].

Barry, JD ;

Graham, SV ;

Fotheringham, M ;

Graham, VS ;

Kobryn, K ;

Wymer, B .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1998, 91 (01) :93-105

[7]

Barry JD, 2001, ADV PARASIT, V49, P1, DOI 10.1016/S0065-308X(01)49037-3

[8] Isolation of the repertoire of VSG expression site containing telomeres of Trypanosoma brucei 427 using transformation-associated recombination in yeast [J].

Becker, M ;

Aitcheson, N ;

Byles, E ;

Wickstead, B ;

Louis, E ;

Rudenko, G .

GENOME RESEARCH, 2004, 14 (11) :2319-2329

[9] ACTIVATION OF TRYPANOSOME SURFACE GLYCOPROTEIN GENES INVOLVES A DUPLICATION-TRANSPOSITION LEADING TO AN ALTERED 3' END [J].

BERNARDS, A ;

VANDERPLOEG, LHT ;

FRASCH, ACC ;

BORST, P ;

BOOTHROYD, JC ;

COLEMAN, S ;

CROSS, GAM .

CELL, 1981, 27 (03) :497-505

[10] The genome of the African trypanosome Trypanosoma brucei [J].

Berriman, M ;

Ghedin, E ;

Hertz-Fowler, C ;

Blandin, G ;

Renauld, H ;

Bartholomeu, DC ;

Lennard, NJ ;

Caler, E ;

Hamlin, NE ;

Haas, B ;

Böhme, W ;

Hannick, L ;

Aslett, MA ;

Shallom, J ;

Marcello, L ;

Hou, LH ;

Wickstead, B ;

Alsmark, UCM ;

Arrowsmith, C ;

Atkin, RJ ;

Barron, AJ ;

Bringaud, F ;

Brooks, K ;

Carrington, M ;

Cherevach, I ;

Chillingworth, TJ ;

Churcher, C ;

Clark, LN ;

Corton, CH ;

Cronin, A ;

Davies, RM ;

Doggett, J ;

Djikeng, A ;

Feldblyum, T ;

Field, MC ;

Fraser, A ;

Goodhead, I ;

Hance, Z ;

Harper, D ;

Harris, BR ;

Hauser, H ;

Hostetter, J ;

Ivens, A ;

Jagels, K ;

Johnson, D ;

Johnson, J ;

Jones, K ;

Kerhornou, AX ;

Koo, H ;

Larke, N .

SCIENCE, 2005, 309 (5733) :416-422

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