Switching trypanosome coats: what's in the wardrobe?

被引：137

作者：

Taylor, Jesse E.

Rudenko, Gloria

机构：

[1] Univ Oxford, Oxford OX1 3SY, England

[2] Univ Oxford, Dept Stat, Oxford OX1 3TG, England

来源：

TRENDS IN GENETICS | 2006年 / 22卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tig.2006.08.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The African trypanosome Trypanosoma brucei is best known for its extraordinarily sophisticated antigenic variation of a protective variant surface glycoprotein (VSG) coat. T. brucei has > 1000 VSG genes and pseudogenes, of which one is transcribed at a time from one of multiple telomeric VSG expression sites. Switching the active VSG gene can involve DNA rearrangements replacing the old VSG with a new one, or alternatively transcriptional control. The astonishing revelation from the T. brucei genome sequence is that < 7% of the sequenced VSGs seem to have fully functional coding regions. This preponderance of pseudogenes in the VSG gene repertoire will necessitate a rethink of how antigenic variation in African trypanosomes operates.

引用

收藏

页码：614 / 620

页数：7

相关论文

共 48 条

[31] A novel mechanism for control of antigenic variation in the haemagglutinin gene family of Mycoplasma synoviae [J].

Noormohammadi, AH ;

Markham, PF ;

Kanci, A ;

Whithear, KG ;

Browning, GF .

MOLECULAR MICROBIOLOGY, 2000, 35 (04) :911-923

[32] The variant surface glycoprotein as a tool for adaptation in African trypanosomes [J].

Pays, E .

MICROBES AND INFECTION, 2006, 8 (03) :930-937

[33] Antigenic variation in Trypanosoma brucei:: facts, challenges and mysteries [J].

Pays, E ;

Vanhamme, L ;

Pérez-Morga, D .

CURRENT OPINION IN MICROBIOLOGY, 2004, 7 (04) :369-374

[34] PSEUDOGENES, CHIMAERIC GENES AND THE TIMING OF ANTIGEN VARIATION IN AFRICAN TRYPANOSOMES [J].

PAYS, E .

TRENDS IN GENETICS, 1989, 5 (12) :389-391

[35] GENE CONVERSION AS A MECHANISM FOR ANTIGENIC VARIATION IN TRYPANOSOMES [J].

PAYS, E ;

VANASSEL, S ;

LAURENT, M ;

DARVILLE, M ;

VERVOORT, T ;

VANMEIRVENNE, N ;

STEINERT, M .

CELL, 1983, 34 (02) :371-381

[36] TRYPANOSOMA BRUCEI - THE EXTENT OF CONVERSION IN ANTIGEN GENES MAY BE RELATED TO THE DNA CODING SPECIFICITY [J].

PAYS, E ;

HOUARD, S ;

PAYS, A ;

VANASSEL, S ;

DUPONT, F ;

AERTS, D ;

HUETDUVILLIER, G ;

GOMES, V ;

RICHET, C ;

DEGAND, P ;

VANMEIRVENNE, N ;

STEINERT, M .

CELL, 1985, 42 (03) :821-829

[37]

Robinson NP, 1999, MOL CELL BIOL, V19, P5839

[38] ACTIVE LATE-APPEARING VARIABLE SURFACE-ANTIGEN GENES IN TRYPANOSOMA-EQUIPERDUM ARE CONSTRUCTED ENTIRELY FROM PSEUDOGENES [J].

ROTH, C ;

BRINGAUD, F ;

LAYDEN, RE ;

BALTZ, T ;

EISEN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9375-9379

[39] Telomere exchange can be an important mechanism of variant surface glycoprotein gene switching in Trypanosoma brucei [J].

Rudenko, G ;

McCulloch, R ;

DirksMulder, A ;

Borst, P .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1996, 80 (01) :65-75

[40] Plasmodium telomeres:: a pathogen's perspective [J].

Scherf, A ;

Figueiredo, LM ;

Freitas-Junior, LH .

CURRENT OPINION IN MICROBIOLOGY, 2001, 4 (04) :409-414

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