The potential of positron-emission tomography to study anticancer-drug resistance

被引：24

作者：

West, CML

Jones, T

Price, P

机构：

[1] Univ Manchester, Christie Hosp NHS Trust, Acad Dept Radiat Oncol, Manchester M20 4BX, Lancs, England

[2] Univ Manchester, Christie Hosp NHS Trust, Manchester Mol Imaging Ctr, Manchester M20 4BX, Lancs, England

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 06期

关键词：

D O I：

10.1038/nrc1368

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Positron-emission tomography (PET) is a powerful tool for imaging and quantifying cellular and molecular processes in humans. It has enormous potential to increase our understanding of the pathophysiology of human tumours and to support the development of anticancer drugs. The ability of PET to image mechanisms of anticancer-drug resistance in vivo should be exploited in proof-of-concept studies at early stages of drug development.

引用

收藏

页码：457 / 469

页数：13

相关论文

共 142 条

[21] Molecular-genetic imaging: current and future perspectives [J].

Blasberg, RG ;

Tjuvajev, AG .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (11) :1620-1629

[22] In vivo molecular-genetic imaging [J].

Blasberg, RG ;

Gelovani-Tjuvajev, J .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, :172-183

[23] Clinical role of positron emission tomography in oncology [J].

Bomanji, J. B. ;

Costa, D. C. ;

Ell, P. J. .

LANCET ONCOLOGY, 2001, 2 (03) :157-164

[24] Potential 18F-labeled biomarkers for epidermal growth factor receptor tyrosine kinase [J].

Bonasera, TA ;

Ortu, G ;

Rozen, Y ;

Krais, R ;

Freedman, NMT ;

Chisin, R ;

Gazit, A ;

Levitzki, A ;

Mishani, E .

NUCLEAR MEDICINE AND BIOLOGY, 2001, 28 (04) :359-374

[25] Oncology's trials [J].

Booth, B ;

Glassman, R ;

Ma, P .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (08) :609-610

[26] Biologic correlates of 18fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography [J].

Bos, R ;

van der Hoeven, JJM ;

van der Wall, E ;

van der Groep, P ;

van Diest, PJ ;

Comans, EFI ;

Joshi, U ;

Semenza, GL ;

Hoekstra, OS ;

Lammertsma, AA ;

Molthoff, CFM .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (02) :379-387

[27] Assessment of the biodistribution and metabolism of 5-fluorouracil as monitored by F-18 PET and F-19 MRI: A comparative animal study [J].

Brix, G ;

Bellemann, ME ;

Haberkorn, U ;

Gerlach, L ;

Lorenz, WJ .

NUCLEAR MEDICINE AND BIOLOGY, 1996, 23 (07) :897-906

[28] Continuous angiotensin II infusion increases tumour: normal blood flow ratio in colo-rectal liver metastases [J].

Burke, D ;

Davies, MM ;

Zweit, J ;

Flower, MA ;

Ott, RJ ;

Dworkin, MJ ;

Glover, C ;

McCready, VR ;

Carnochan, P ;

Allen-Mersh, TG .

BRITISH JOURNAL OF CANCER, 2001, 85 (11) :1640-1645

[29]

Burke D, 2001, CLIN EXP METASTAS, V18, P617

[30] Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361 [J].

Calabrese, CR ;

Almassy, R ;

Barton, S ;

Batey, MA ;

Calvert, AH ;

Canan-Koch, S ;

Durkacz, BW ;

Hostomsky, Z ;

Kumpf, RA ;

Kyle, S ;

Li, J ;

Maegley, K ;

Newell, DR ;

Notarianni, E ;

Stratford, IJ ;

Skalitzky, D ;

Thomas, HD ;

Wang, LZ ;

Webber, SE ;

Williams, KJ ;

Curtin, NJ .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (01) :56-67

← 1 2 3 4 5 6 7 8 9 10 →