5-HT1D-like receptors inhibit the release of endogenously formed [H-3]GABA in human, but not in rabbit, neocortex

被引：22

作者：

Feuerstein, TJ ^{[1
]}

Huring, H ^{[1
]}

vanVelthoven, V ^{[1
]}

Lucking, CH ^{[1
]}

Landwehrmeyer, GB ^{[1
]}

机构：

[1] UNIV FREIBURG,NEUROCHIRURG KLIN,D-79106 FREIBURG,GERMANY

来源：

NEUROSCIENCE LETTERS | 1996年 / 209卷 / 03期

关键词：

gamma-aminobutyric acid (GABA) release; 5-hydroxytryptamine (5-HT)(1D)-like heteroreceptors; human neocortex; rabbit neocortex; 5-HT/GABA interaction; species difference; anxiety disorders;

D O I：

10.1016/0304-3940(96)12637-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Both human and rabbit brain contain the 5-hydroxytryptamine (5-HT)(1D) subtype of 5-HT1 receptors, We studied the effects of 5-HT1D receptor stimulation on neocortical [H-3]gamma-aminobutyric acid (GABA) release from GABAergic neurons in these species. The 5-HT1D receptor agonist sumatriptan depressed [H-3]GABA release in human neocortex and the 5-HT1 receptor antagonist metitepin prevented this depression with potencies suggesting mediation by 5-HT1D-like receptors. In rabbit neocortex, however, 5-HT1D agonists did not affect the release of [H-3]GABA. Since 5-HT and GABA seem to function antagonistically in anxiety disorders their neocortical interaction may be (patho)physiologically relevant.

引用

页码：210 / 214

页数：5

共 26 条

[21]

WAEBER C, 1989, N-S ARCH PHARMACOL, V340, P479

[22] VISUALIZATION OF A NOVEL SEROTONIN RECOGNITION SITE (5-HT1D) IN THE HUMAN-BRAIN BY AUTORADIOGRAPHY [J].

WAEBER, C ;

DIETL, MM ;

HOYER, D ;

PROBST, A ;

PALACIOS, JM .

NEUROSCIENCE LETTERS, 1988, 88 (01) :11-16

[23] NON-5-HT1A/5-HT1C [H-3] 5-HT BINDING-SITES IN THE HAMSTER, OPOSSUM, AND RABBIT BRAIN SHOW SIMILAR REGIONAL DISTRIBUTION BUT DIFFERENT SENSITIVITY TO BETA-ADRENOCEPTOR ANTAGONISTS [J].

WAEBER, C ;

PALACIOS, JM .

SYNAPSE, 1992, 12 (04) :261-270

[24] HUMAN SEROTONIN-1D RECEPTOR IS ENCODED BY A SUBFAMILY OF 2 DISTINCT GENES - 5-HT(1D-ALPHA) AND 5-HT(1D-BETA) [J].

WEINSHANK, RL ;

ZGOMBICK, JM ;

MACCHI, MJ ;

BRANCHEK, TA ;

HARTIG, PR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3630-3634

[25]

WESTLAKE WJ, 1981, BIOMETRICS, V37, P591

[26] PREFERENTIAL RELEASE OF NEWLY SYNTHESIZED [H-3]GABA FROM STRIATAL SLICES TO PRELOADED [H-3]GABA [J].

YONEDA, Y ;

KANMORI, K ;

TAKAHASHI, M ;

ZUO, PP ;

PAIK, IH ;

KURIYAMA, K .

NEUROCHEMISTRY INTERNATIONAL, 1984, 6 (05) :641-649

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