Lighting up mRNA localization in Drosophila oogenesis

被引:105
作者
Becalska, Agata N. [1 ]
Gavis, Elizabeth R. [1 ]
机构
[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
来源
DEVELOPMENT | 2009年 / 136卷 / 15期
基金
加拿大自然科学与工程研究理事会; 美国国家卫生研究院;
关键词
RESTRICTS POLE PLASM; POSTERIOR LOCALIZATION; BICOID RNA; KINESIN-I; INTRACELLULAR-LOCALIZATION; TRANSLATIONAL CONTROL; AXIS SPECIFICATION; PROTEIN-SYNTHESIS; CELL-FORMATION; GERM PLASM;
D O I
10.1242/dev.032391
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The asymmetric localization of four maternal mRNAs - gurken, bicoid, oskar and nanos - in the Drosophila oocyte is essential for the development of the embryonic body axes. Fluorescent imaging methods are now being used to visualize these mRNAs in living tissue, allowing dynamic analysis of their behaviors throughout the process of localization. This review summarizes recent findings from such studies that provide new insight into the elaborate cellular mechanisms that are used to transport mRNAs to different regions of the oocyte and to maintain their localized distributions during oogenesis.
引用
收藏
页码:2493 / 2503
页数:11
相关论文
共 76 条
[1]   Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila [J].
Ashraf, SI ;
McLoon, AL ;
Sclarsic, SM ;
Kunes, S .
CELL, 2006, 124 (01) :191-205
[2]   Localization of ASH1 mRNA particles in living yeast [J].
Bertrand, E ;
Chartrand, P ;
Schaefer, M ;
Shenoy, SM ;
Singer, RH ;
Long, RM .
MOLECULAR CELL, 1998, 2 (04) :437-445
[3]   Spatial regulation of nanos is required for its function in dendrite morphogenesis [J].
Brechbiel, Jillian L. ;
Gavis, Elizabeth R. .
CURRENT BIOLOGY, 2008, 18 (10) :745-750
[4]   Oskar protein interaction with Vasa represents an essential step in polar granule assembly [J].
Breitwieser, W ;
Markussen, FH ;
Horstmann, H ;
Ephrussi, A .
GENES & DEVELOPMENT, 1996, 10 (17) :2179-2188
[5]   A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein [J].
Brendza, RP ;
Serbus, LR ;
Duffy, JB ;
Saxton, WM .
SCIENCE, 2000, 289 (5487) :2120-2122
[6]  
CARSON JH, 1993, J CELL BIOL, V123, P431
[7]   Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior [J].
Cha, BJ ;
Serbus, LR ;
Koppetsch, BS ;
Theurkauf, WE .
NATURE CELL BIOLOGY, 2002, 4 (08) :592-598
[8]   In vivo analysis of Drosophila bicoid mRNA localization reveals a novel microtubule-dependent axis specification pathway [J].
Cha, BJ ;
Koppetsch, BS ;
Theurkauf, WE .
CELL, 2001, 106 (01) :35-46
[9]   A Dynein-dependent shortcut rapidly delivers axis determination transcripts into the Drosophila oocyte [J].
Clark, Alejandra ;
Meignin, Carine ;
Davis, Ilan .
DEVELOPMENT, 2007, 134 (10) :1955-1965
[10]   TRANSIENT POSTERIOR LOCALIZATION OF A KINESIN FUSION PROTEIN REFLECTS ANTEROPOSTERIOR POLARITY OF THE DROSOPHILA OOCYTE [J].
CLARK, I ;
GINIGER, E ;
RUOHOLABAKER, H ;
JAN, LY ;
JAN, YN .
CURRENT BIOLOGY, 1994, 4 (04) :289-300