Lighting up mRNA localization in Drosophila oogenesis

被引：105

作者：

Becalska, Agata N. ^{[1
]}

Gavis, Elizabeth R. ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

DEVELOPMENT | 2009年 / 136卷 / 15期

基金：

加拿大自然科学与工程研究理事会; 美国国家卫生研究院;

关键词：

RESTRICTS POLE PLASM; POSTERIOR LOCALIZATION; BICOID RNA; KINESIN-I; INTRACELLULAR-LOCALIZATION; TRANSLATIONAL CONTROL; AXIS SPECIFICATION; PROTEIN-SYNTHESIS; CELL-FORMATION; GERM PLASM;

D O I：

10.1242/dev.032391

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The asymmetric localization of four maternal mRNAs - gurken, bicoid, oskar and nanos - in the Drosophila oocyte is essential for the development of the embryonic body axes. Fluorescent imaging methods are now being used to visualize these mRNAs in living tissue, allowing dynamic analysis of their behaviors throughout the process of localization. This review summarizes recent findings from such studies that provide new insight into the elaborate cellular mechanisms that are used to transport mRNAs to different regions of the oocyte and to maintain their localized distributions during oogenesis.

引用

页码：2493 / 2503

页数：11

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