Rheumatoid cachexia: a complication of rheumatoid arthritis moves into the 21st century

被引：79

作者：

Roubenoff, Ronenn ^{[1
,2
,3
]}

机构：

[1] Biogen Idec Inc, Immunol R&D, Cambridge, MA 02142 USA

[2] Tufts Univ, Boston, MA 02111 USA

[3] Tufts Med Ctr, Boston, MA 02111 USA

来源：

ARTHRITIS RESEARCH & THERAPY | 2009年 / 11卷 / 02期

关键词：

TUMOR-NECROSIS-FACTOR; LEAN BODY-MASS; PROTEIN-METABOLISM; FACTOR-ALPHA; INFLAMMATION; ASSOCIATION; DISABILITY;

D O I：

10.1186/ar2658

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Rheumatoid cachexia, loss of muscle mass and strength and concomitant increase in fat mass, is very common in patients with rheumatoid arthritis (RA). Despite great advances in the treatment of RA, it appears that rheumatoid cachexia persists even after joint inflammation improves. Rheumatoid cachexia may be an important risk factor for cardiovascular disease and excess mortality in RA. In this issue of Arthritis Research & Therapy, Elkan and colleagues demonstrate a link between rheumatoid cachexia and metabolic syndrome, further reinforcing the need for therapy directed beyond inflammation and at the metabolic consequences of RA.

引用

页数：2

共 14 条

[1]

Inflammation-associated insulin resistance - Differential effects in rheumatoid arthritis and systemic lupus erythematosus define potential mechanisms [J].

Chung, Cecilia P. ;

Oeser, Annette ;

Solus, Joseph F. ;

Gebretsadik, Tebeb ;

Shintani, Ayumi ;

Avalos, Ingrid ;

Sokka, Tuulikki ;

Raggi, Paolo ;

Pincus, Theodore ;

Stein, C. Michael .

ARTHRITIS AND RHEUMATISM, 2008, 58 (07) :2105-2112

[2]

Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study [J].

Elkan, Ann-Charlotte ;

Hakansson, Niclas ;

Frostegard, Johan ;

Cederholm, Tommy ;

Hafstrom, Ingiald .

ARTHRITIS RESEARCH & THERAPY, 2009, 11 (02)

[3]

Cachexia in rheumatoid arthritis is associated with inflammatory activity, physical disability, and low bioavailable insulin-like growth factor [J].

Engvall, I-L ;

Elkan, A-C ;

Tengstrand, B. ;

Cederholm, T. ;

Brismar, K. ;

Hafstrom, I. .

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2008, 37 (05) :321-328

[4]

Association of Body Composition With Disability in Rheumatoid Arthritis: Impact of Appendicular Fat and Lean Tissue Mass [J].

Giles, Jon T. ;

Bartlett, Susan J. ;

Andersen, Ross E. ;

Fontaine, Kevin R. ;

Bathon, Joan M. .

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2008, 59 (10) :1407-1415

[5]

NF-κB-induced loss of MyoD messenger RNA:: Possible role in muscle decay and cachexia [J].

Guttridge, DC ;

Mayo, MW ;

Madrid, LV ;

Wang, CY ;

Baldwin, AS .

SCIENCE, 2000, 289 (5488) :2363-2366

[6]

Prognostic importance of low body mass index in relation to cardiovascular mortality in rheumatoid arthritis [J].

Kremers, HM ;

Nicola, PJ ;

Crowson, CS ;

Ballman, KV ;

Gabriel, SE .

ARTHRITIS AND RHEUMATISM, 2004, 50 (11) :3450-3457

[7]

Blockade of tumour necrosis factor-α in rheumatoid arthritis:: effects on components of rheumatoid cachexia [J].

Metsios, G. S. ;

Stavropoulos-Kalinoglou, A. ;

Douglas, K. M. J. ;

Koutedakis, Y. ;

Nevill, A. M. ;

Panoulas, V. F. ;

Kita, M. ;

Kitas, G. D. .

RHEUMATOLOGY, 2007, 46 (12) :1824-1827

[8]

PAGET J, 1873, LANCET, V2, P727

[9]

Protein metabolism in rheumatoid arthritis and aging - Effects of muscle strength training and tumor necrosis factor alpha [J].

Rall, LC ;

Rosen, CJ ;

Dolnikowski, G ;

Hartman, WJ ;

Lundgren, N ;

Abad, LW ;

Dinarello, CA ;

Roubenoff, R .

ARTHRITIS AND RHEUMATISM, 1996, 39 (07) :1115-1124

[10]

Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion [J].

Rall, LC ;

Walsmith, JM ;

Snydman, L ;

Reichlin, S ;

Veldhuis, JD ;

Kehayias, JJ ;

Abad, LW ;

Lundgren, NT ;

Roubenoff, R .

ARTHRITIS AND RHEUMATISM, 2002, 46 (10) :2574-2577

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