HIV and CXCR4 in a kiss of autophagic death

被引：12

作者：

Levine, Beth

Sodora, Donald L.

机构：

[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Microbiol, Dallas, TX 75390 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 08期

关键词：

D O I：

10.1172/JCI29447

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

AIDS is characterized by CD4(+) T lymphocyte depletion, yet the mechanisms underlying this central aspect of HIV pathogenesis are still poorly understood. In this issue of the JCI, Espert et al. identify a mechanism by which the HIV envelope glycoprotein can induce death in uninfected CD4(+) T cells (see the related article beginning on page 2161). The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and non-apoptotic cell death.

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页码：2078 / 2080

页数：3

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