Pleural Tuberculosis in Patients with Early HIV Infection Is Associated with Increased TNF-Alpha Expression and Necrosis in Granulomas

被引：32

作者：

Bezuidenhout, Juanita ^{[1
]}

Roberts, Teri ^{[2
]}

Muller, Liesel ^{[2
]}

van Helden, Paul ^{[2
]}

Walzl, Gerhard ^{[2
]}

机构：

[1] Tygerberg Hosp, Dept Histopathol, Cape Town, Western Cape, South Africa

[2] Univ Stellenbosch, Fac Hlth Sci, Dept Biomed Sci, DST, Ctr Excellence Biomed TB Res, NRF, ZA-7600 Stellenbosch, South Africa

来源：

PLOS ONE | 2009年 / 4卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

PROTECTIVE IMMUNE-RESPONSE; INTERFERON-GAMMA-RECEPTOR; MYCOBACTERIUM-TUBERCULOSIS; T-CELLS; MACROPHAGE APOPTOSIS; MESSENGER-RNA; IFN-GAMMA; IN-VITRO; CYTOKINE; IMMUNODEFICIENCY;

D O I：

10.1371/journal.pone.0004228

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although granulomas may be an essential host response against persistent antigens, they are also associated with immunopathology. We investigated whether HIV co-infection affects histopathological appearance and cytokine profiles of pleural granulomas in patients with active pleural tuberculosis (TB). Granulomas were investigated in pleural biopsies from HIV positive and negative TB pleuritis patients. Granulomas were characterised as necrotic or non-necrotic, graded histologically and investigated for the mRNA expression of IL-12, IFN-gamma, TNF-alpha and IL-4 by in situ hybridisation. In all TB patients a mixed Th1/Th2 profile was noted. Necrotic granulomas were more evident in HIV positive patients with a clear association between TNF- alpha and necrosis. This study demonstrates immune dysregulation which may include TNF-alpha-mediated immunopathology at the site of disease in HIV infected pleural TB patients.

引用

页数：8

共 63 条

[41] SPECTRUM OF IMMUNODEFICIENCY IN HIV-1-INFECTED PATIENTS WITH PULMONARY TUBERCULOSIS IN ZAIRE [J].

MUKADI, Y ;

PERRIENS, JH ;

STLOUIS, ME ;

BROWN, C ;

PRIGNOT, J ;

WILLAME, JC ;

POUTHIER, F ;

KABOTO, M ;

RYDER, RW ;

PORTAELS, F ;

PIOT, P .

LANCET, 1993, 342 (8864) :143-146

[42]

MULLER KM, 1993, J IMMUNOL, V150, P5576

[43] DETECTION OF TUMOR-NECROSIS-FACTOR-ALPHA IN SARCOIDOSIS AND TUBERCULOSIS GRANULOMAS USING IN-SITU HYBRIDIZATION [J].

MYATT, N ;

COGHILL, G ;

MORRISON, K ;

JONES, D ;

CREE, IA .

JOURNAL OF CLINICAL PATHOLOGY, 1994, 47 (05) :423-426

[44] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN GP120 PRODUCES IMMUNE DEFECTS IN CD4+ LYMPHOCYTES-T BY INHIBITING INTERLEUKIN-2 MESSENGER-RNA [J].

OYAIZU, N ;

CHIRMULE, N ;

KALYANARAMAN, VS ;

HALL, WW ;

GOOD, RA ;

PAHWA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) :2379-2383

[45]

Polyak S, 1997, J IMMUNOL, V159, P2177

[46] TNF-induced signaling in apoptosis [J].

Rath, PC ;

Aggarwal, BB .

JOURNAL OF CLINICAL IMMUNOLOGY, 1999, 19 (06) :350-364

[47] Distinct response kinetics of gamma interferon and interleukin-4 in bovine tuberculosis [J].

Rhodes, SG ;

Palmer, N ;

Graham, SP ;

Bianco, AE ;

Hewinson, RG ;

Vordermeier, HM .

INFECTION AND IMMUNITY, 2000, 68 (09) :5393-5400

[48] TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection [J].

Roach, DR ;

Bean, AGD ;

Demangel, C ;

France, MP ;

Briscoe, H ;

Britton, WJ .

JOURNAL OF IMMUNOLOGY, 2002, 168 (09) :4620-4627

[49]

ROPER WH, 1955, AM REV TUBERC PULM, V71, P616

[50] Direct evidence of secondary necrosis of neutrophils during intense lung inflammation [J].

Rydell-Tormanen, K. ;

Uller, L. ;

Erjefalt, J. S. .

EUROPEAN RESPIRATORY JOURNAL, 2006, 28 (02) :268-274

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