Association between immune recovery uveitis and a diverse intraocular cytomegalovirus-specific cytotoxic T cell response

被引:34
作者
Mutimer, HP
Akatsuka, Y
Manley, T
Chuang, EL
Boeckh, M
Harrington, R
Jones, T
Riddell, SR
机构
[1] Univ Washington, Fred Hutchinson Canc Res Ctr, Program Immunol, Seattle, WA 98195 USA
[2] Univ Washington, Dept Ophthalmol, Seattle, WA 98195 USA
[3] Univ Washington, Dept Med, Seattle, WA 98195 USA
[4] Wyeth Ayerst Res, Pearl River, NY USA
关键词
D O I
10.1086/342044
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cytomegalovirus (CMV) causes serious infection in individuals with deficient T cell immunity. In acquired immunodeficiency syndrome, the retina is a major site of progressive infection, despite the availability of therapy that targets CMV. The administration of highly active antiretroviral therapy to suppress human immunodeficiency virus frequently results in resolution of CMV retinitis, but this may be complicated by ocular inflammation termed "immune recovery uveitis" (IRU). To provide insight into the pathogenesis of IRU, the phenotype and specificity of intraocular T cells in a single patient were analyzed. The T cell infiltrate consisted of a diverse population of CD8(+) CMV-specific T cells, but only a minority of these T cells recognized the CMV phosphoprotein 65 and immediate early protein 1, which have been considered major targets of the host response. These results imply that reconstitution of CMV-specific T cells plays a role in IRU and suggest that the specificity of T cells engaged in the control of CMV at local sites of reactivation may be broad.
引用
收藏
页码:701 / 705
页数:5
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