学术探索
学术期刊
新闻热点
数据分析
智能评审

Viral strategies of immune evasion

被引：643
作者：
Ploegh, HL [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
来源：
SCIENCE | 1998年 / 280卷 / 5361期
关键词：
D O I：
10.1126/science.280.5361.248
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The vertebrate body is an ideal breeding ground for viruses and provides the conditions that promote their growth, survival, and transmission. The immune system evolved and deals with this challenge. Mutually assured destruction is not a viable evolutionary strategy; thus, the study of host-virus interactions provides not only a glimpse of life at immunity's edge, but it has also illuminated essential functions of the immune system, in particular, the area of major histocompatibility complex-restricted antigen presentation.
引用
收藏
页码：248 / 253
页数：6
相关论文
共 54 条
  • [1] The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP
    Ahn, K
    Gruhler, A
    Galocha, B
    Jones, TR
    Wiertz, EJHJ
    Ploegh, HL
    Peterson, PA
    Yang, Y
    Fruh, K
    [J]. IMMUNITY, 1997, 6 (05) : 613 - 621
  • [2] Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus protein ICP47
    Ahn, K
    Meyer, TH
    Uebel, S
    Sempe, P
    Djaballah, H
    Yang, Y
    Peterson, PA
    Fruh, K
    Tampe, R
    [J]. EMBO JOURNAL, 1996, 15 (13) : 3247 - 3255
  • [3] Human cytomegalovirus inhibits antigen presentation by a sequential multistep process
    Ahn, KS
    Angulo, A
    Ghazal, P
    Peterson, PA
    Yang, Y
    Fruh, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (20) : 10990 - 10995
  • [4] NEF INDUCES CD4 ENDOCYTOSIS - REQUIREMENT FOR A CRITICAL DILEUCINE MOTIF IN THE MEMBRANE-PROXIMAL CD4 CYTOPLASMIC DOMAIN
    AIKEN, C
    KONNER, J
    LANDAU, NR
    LENBURG, ME
    TRONO, D
    [J]. CELL, 1994, 76 (05) : 853 - 864
  • [5] VACUOLAR H+-ATPASE MUTANTS TRANSFORM CELLS AND DEFINE A BINDING-SITE FOR THE PAPILLOMAVIRUS E5 ONCOPROTEIN
    ANDRESSON, T
    SPARKOWSKI, J
    GOLDSTEIN, DJ
    SCHLEGEL, R
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (12) : 6830 - 6837
  • [6] NATURAL VARIANTS OF CYTOTOXIC EPITOPES ARE T-CELL RECEPTOR ANTAGONISTS FOR ANTIVIRAL CYTOTOXIC T-CELLS
    BERTOLETTI, A
    SETTE, A
    CHISARI, FV
    PENNA, A
    LEVRERO, M
    DECARLI, M
    FIACCADORI, F
    FERRARI, C
    [J]. NATURE, 1994, 369 (6479) : 407 - 410
  • [7] COLLINS KL, IN PRESS NATURE
  • [8] A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules
    Cosman, D
    Fanger, N
    Borges, L
    Kubin, M
    Chin, W
    Peterson, L
    Hsu, ML
    [J]. IMMUNITY, 1997, 7 (02) : 273 - 282
  • [9] The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole
    Cowles, CR
    Odorizzi, G
    Payne, GS
    Emr, SD
    [J]. CELL, 1997, 91 (01) : 109 - 118
  • [10] DAVISPOYNTER NJ, IN PRESS SEMIN VIROL
123456