Prediction of the three-dimensional structure of the human Fas receptor by comparative molecular modeling

被引：12

作者：

Bajorath, J ^{[1
]}

Aruffo, A ^{[1
]}

机构：

[1] UNIV WASHINGTON,DEPT BIOL STRUCT,SEATTLE,WA 98195

来源：

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN | 1997年 / 11卷 / 01期

关键词：

protein structure prediction; comparative modeling; TNFR superfamily; cell surface receptor; receptor-ligand interaction;

D O I：

10.1023/A:1008011024584

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Fas antigen, a cell surface receptor belonging to the tumor necrosis factor receptor (TNFR) superfamily, triggers programmed cell death (apoptosis) in the immune system. The three-dimensional structure of Fas and molecular details of the interaction between Fas and its ligand are currently unknown. A three-dimensional model of the Fas extracellular region was generated by comparative modeling. Inverse folding analysis suggested good sequence-structure compatibility of the model and thus reasonable accuracy. The model was analyzed in the light of information provided by studies on TNFR and CD40, another member of the TNFR family, and the Fas ligand binding site was predicted.

引用

页码：3 / 8

页数：6

共 22 条

[1] KNOWLEDGE-BASED MODEL-BUILDING OF PROTEINS - CONCEPTS AND EXAMPLES [J].