The effector repertoire of enteropathogenic E-coli: ganging up on the host cell

被引:165
作者
Dean, Paul [1 ]
Kenny, Brendan [1 ]
机构
[1] Univ Newcastle, Inst Cell & Mol Biosci, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
基金
英国惠康基金;
关键词
III SECRETION SYSTEM; CITROBACTER-RODENTIUM INFECTION; HUMAN INTESTINAL-MUCOSA; DISRUPTION IN-VIVO; ACTIN POLYMERIZATION; EFFACING PATHOGENS; SIGNALING PATHWAYS; SHIGELLA-FLEXNERI; VIRULENCE FACTOR; ESPF INTERACTS;
D O I
10.1016/j.mib.2008.11.006
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Diarrhoeal disease caused by enteropathogenic E. coli (EPEC) is dependent on a delivery system that injects numerous bacterial 'effector' proteins directly into host cells. The best-described EPEC effectors are encoded together on the locus of enterocyte effacement (LEE) pathogenicity island and display high levels of multifunctionality and cooperativity within the host cell. More recently, effectors encoded outside the LEE (non-LEE effectors) have been discovered and their functions are beginning to be uncovered. The recent completion of the EPEC genome sequence suggests its effector repertoire consists of at least 21 effector proteins. Here, we describe the genomic location of effectors and discuss recent advances made on effector cellular function as well as their role in the infection process.
引用
收藏
页码:101 / 109
页数:9
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