Prognostic significance of TGF-alpha expression in breast cancer

被引:12
作者
Auvinen, PK [1 ]
Lipponen, PK [1 ]
Kataja, VV [1 ]
Johansson, RT [1 ]
Syrjanen, KJ [1 ]
机构
[1] UNIV KUOPIO, DEPT PATHOL, KUOPIO, FINLAND
关键词
D O I
10.3109/02841869609100717
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A series of breast cancer biopsies from 204 women were analysed immunohistochemically for the expression of transforming growth factor alpha (TGF-alpha). Expression of TGF-alpha was intense in 119 cases (58%), weak in 63 (31%), and totally absent in 22 (11%) of the cases. No correlation was observed between the expression of TGF-alpha and tumour size, metastasis at diagnosis, histological type and grade, ER and PR status, DNA index, S-phase fraction or the expression of TGF-beta 1 or beta 2, However, the expression of TGF-alpha was significantly related to axillary lymph node metastasis and to low survival probability during the follow-up, These data support the earlier observations on the in vitro studies, suggesting that TGF-alpha most probably exerts an in vivo growth stimulation of female breast cancer cells.
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收藏
页码:995 / 998
页数:4
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