Prognostic significance of TGF-alpha expression in breast cancer

被引：12

作者：

Auvinen, PK ^{[1
]}

Lipponen, PK ^{[1
]}

Kataja, VV ^{[1
]}

Johansson, RT ^{[1
]}

Syrjanen, KJ ^{[1
]}

机构：

[1] UNIV KUOPIO, DEPT PATHOL, KUOPIO, FINLAND

来源：

ACTA ONCOLOGICA | 1996年 / 35卷 / 08期

关键词：

D O I：

10.3109/02841869609100717

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A series of breast cancer biopsies from 204 women were analysed immunohistochemically for the expression of transforming growth factor alpha (TGF-alpha). Expression of TGF-alpha was intense in 119 cases (58%), weak in 63 (31%), and totally absent in 22 (11%) of the cases. No correlation was observed between the expression of TGF-alpha and tumour size, metastasis at diagnosis, histological type and grade, ER and PR status, DNA index, S-phase fraction or the expression of TGF-beta 1 or beta 2, However, the expression of TGF-alpha was significantly related to axillary lymph node metastasis and to low survival probability during the follow-up, These data support the earlier observations on the in vitro studies, suggesting that TGF-alpha most probably exerts an in vivo growth stimulation of female breast cancer cells.

引用

页码：995 / 998

页数：4

共 23 条

[21] IMMUNOHISTOCHEMICAL STUDIES ON ONCOGENE PRODUCTS (EGF-R, C-ERBB-2) AND GROWTH-FACTORS (EGF, TGF-ALPHA) IN HUMAN BREAST-CANCER - THEIR RELATIONSHIP TO ESTROGEN-RECEPTOR STATUS, HISTOLOGICAL GRADE, MITOTIC INDEX AND NODAL STATUS [J].