Medical applications of magnetic nanoparticles

被引:101
作者
Alexiou, C. [1 ]
Jurgons, R. [1 ]
Seliger, C. [1 ]
Iro, H. [1 ]
机构
[1] Univ Erlangen Nurnberg, Dept Otorhinolaryngol Head & Neck Surg, D-8520 Erlangen, Germany
关键词
D O I
10.1166/jnn.2006.464
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In recent years biomedical research indicated, that magnetic nanoparticles can be a promising tool for several applications in vitro and in vivo. In medicine many approaches were investigated for diagnosis and therapy and offered a great variety of applications. Magnetic cell separation, magnetic resonance imaging (MRI), magnetic targeted delivery of therapeutics or magnetically induced hyperthermia are approaches of particular clinical relevance. For medical use, especially for in vivo application it is of great importance that these particles do not have any toxic effects or incompatibility with biological organism. Investigations on applicable particles induced a variability of micro- and nanostructures with different materials, sizes, and specific surface chemistry.
引用
收藏
页码:2762 / 2768
页数:7
相关论文
共 100 条
[61]   MAGNETIC SEPARATION TECHNIQUES IN DIAGNOSTIC MICROBIOLOGY [J].
OLSVIK, O ;
POPOVIC, T ;
SKJERVE, E ;
CUDJOE, KS ;
HORNES, E ;
UGELSTAD, J ;
UHLEN, M .
CLINICAL MICROBIOLOGY REVIEWS, 1994, 7 (01) :43-54
[62]   Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice [J].
Oyewumi, MO ;
Yokel, RA ;
Jay, M ;
Coakley, T ;
Mumper, RJ .
JOURNAL OF CONTROLLED RELEASE, 2004, 95 (03) :613-626
[63]   Applications of magnetic nanoparticles in biomedicine [J].
Pankhurst, QA ;
Connolly, J ;
Jones, SK ;
Dobson, J .
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2003, 36 (13) :R167-R181
[64]   Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells [J].
Petri-Fink, A ;
Chastellain, M ;
Juillerat-Jeanneret, L ;
Ferrari, A ;
Hofmann, H .
BIOMATERIALS, 2005, 26 (15) :2685-2694
[65]   Magnetofection: Enhancing and targeting gene delivery with superparamagnetic nanoparticles and magnetic fields [J].
Plank, C ;
Scherer, F ;
Schillinger, U ;
Bergemann, C ;
Anton, M .
JOURNAL OF LIPOSOME RESEARCH, 2003, 13 (01) :29-32
[66]  
Plank C, 2003, EXPERT OPIN BIOL TH, V3, P745, DOI 10.1517/eobt.3.5.745.21225
[67]   SUPERPARAMAGNETIC IRON-OXIDE NANOPARTICLES AS A LIVER MRI CONTRAST AGENT - CONTRIBUTION OF MICROENCAPSULATION TO IMPROVED BIODISTRIBUTION [J].
POULIQUEN, D ;
PERDRISOT, R ;
ERMIAS, A ;
AKOKA, S ;
JALLET, P ;
LEJEUNE, JJ .
MAGNETIC RESONANCE IMAGING, 1989, 7 (06) :619-627
[68]   Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier (MTC) [J].
Rudge, S ;
Peterson, C ;
Vessely, C ;
Koda, J ;
Stevens, S ;
Catterall, L .
JOURNAL OF CONTROLLED RELEASE, 2001, 74 (1-3) :335-340
[69]  
Sachdeva M S, 1998, Expert Opin Investig Drugs, V7, P1849, DOI 10.1517/13543784.7.11.1849
[70]   Use of magnetic techniques for the isolation of cells [J].
Safarik, I ;
Safaríková, M .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1999, 722 (1-2) :33-53