共 23 条
Weak functional constraints on phosphoproteomes
被引:238
作者:

Landry, Christian R.
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Robert Cedergren BioInformat & Genom, Dept Biochim, Montreal, PQ H3C 3J7, Canada Ctr Robert Cedergren BioInformat & Genom, Dept Biochim, Montreal, PQ H3C 3J7, Canada

Levy, Emmanuel D.
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h-index: 0
机构:
Ctr Robert Cedergren BioInformat & Genom, Dept Biochim, Montreal, PQ H3C 3J7, Canada Ctr Robert Cedergren BioInformat & Genom, Dept Biochim, Montreal, PQ H3C 3J7, Canada

Michnick, Stephen W.
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h-index: 0
机构:
Ctr Robert Cedergren BioInformat & Genom, Dept Biochim, Montreal, PQ H3C 3J7, Canada Ctr Robert Cedergren BioInformat & Genom, Dept Biochim, Montreal, PQ H3C 3J7, Canada
机构:
[1] Ctr Robert Cedergren BioInformat & Genom, Dept Biochim, Montreal, PQ H3C 3J7, Canada
关键词:
PHOSPHORYLATION SITE DATABASE;
PROTEIN-PHOSPHORYLATION;
UNSTRUCTURED PROTEINS;
EVOLUTIONARY;
CONSERVATION;
REVEALS;
REGIONS;
YEAST;
D O I:
10.1016/j.tig.2009.03.003
中图分类号:
Q3 [遗传学];
学科分类号:
071007 ;
090102 ;
摘要:
Owing to their crucial roles in regulating protein function, phosphorylation sites (phosphosites) are expected to be evolutionarily conserved. However, mixed results regarding this prediction have been reported. We resolve these contrasting conclusions to show that phosphosites are, on average, more conserved than non-phosphorylated equivalent residues when their enrichment in disordered regions of proteins is taken into account. Phosphosites of known function are dramatically more conserved than those with no characterized function, indicating that the apparent rapid evolution of phosphoproteomes results from a large fraction of phosphosites being non-functional. Our findings highlight the need to use evolutionary information to identify functional regulatory features such as post-translational modifications of eukaryotic proteomes.
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收藏
页码:193 / 197
页数:5
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