The regulation of protein function by multisite phosphorylation - a 25 year update

被引：883

作者：

Cohen, P ^{[1
]}

机构：

[1] Univ Dundee, MRC, Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2000年 / 25卷 / 12期

关键词：

D O I：

10.1016/S0968-0004(00)01712-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The phosphorylation of a protein can alter its behaviour in almost every conceivable way. These include modulation of its intrinsic biological activity, subcellular location, half-life and docking with other proteins. 'Multisite phosphorylation can enable several such effects to operate in the same protein, It can also determine the extent and duration of a response and is the key to signal integration.

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页码：596 / 601

页数：6

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