Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats

被引：172

作者：

Mao, Yan-Fei ^{[1
]}

Zheng, Xing-Feng ^{[2
,3
]}

Cai, Jian-Mei ^{[4
]}

You, Xin-Min ^{[1
]}

Deng, Xiao-Ming ^{[5
]}

Zhang, John H. ^{[6
]}

Jiang, Lai ^{[1
,5
]}

Sun, Xue-Jun ^{[4
]}

机构：

[1] Shanghai Jiao Tong Univ, Dept Surg Intens Care Unit, Xinhua Hosp, Sch Med, Shanghai 200092, Peoples R China

[2] Second Mil Med Univ, Chinese PLA Inst Burn Surg, Shanghai 200433, Peoples R China

[3] Second Mil Med Univ, Dept Burn Surg, Changhai Hosp, Shanghai 200433, Peoples R China

[4] Second Mil Med Univ, Dept Diving Med, Shanghai 200433, Peoples R China

[5] Chonghai Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China

[6] Loma Linda Univ, Dept Neurosurg, Loma Linda, CA 92350 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 381卷 / 04期

关键词：

Intestinal ischemia/reperfusion; Oxidative stress; Lung injury; Antioxidant; Hydrogen-rich saline; ISCHEMIA-REPERFUSION INJURY; NITRIC-OXIDE; MODEL; ANTIOXIDANT; STRESS; CELLS;

D O I：

10.1016/j.bbrc.2009.02.105

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Objective. Hydrogen has been reported to selectively reduce the hydroxyl radical, the most cytotoxic of reactive oxygen species. In this study we investigated the effects of hydrogen-rich saline on the prevention of lung injury induced by intestinal ischemia/reperfusion (I/R) in rats. Methods. Male Sprague-Dawley rats (n = 30, 200-220 g) were divided randomly into three experimental groups: sham operated, intestinal I/R plus saline treatment (5 ml/kg, i.v.), and intestinal I/R plus hydrogen-rich saline treatment (5 ml/kg, i.v.) groups. Intestinal I/R was produced by 90 min of intestinal ischemia followed by a 4 h of reperfusion. Results. Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-kappa B activation and the pro-inflammatory cytokine interleukin IL-1 beta and TNF-alpha in the lung tissues compared with those in saline-treated rat. Conclusion. Hydrogen-rich saline attenuates lung injury induced by intestinal I/R. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：602 / 605

页数：4

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