Congenital Heart Block Not Associated with Anti-Ro/La Antibodies: Comparison with Anti-Ro/La-positive Cases

被引：24

作者：

Brucato, Antonio ^{[1
]}

Grava, Chiara ^{[4
]}

Bortolati, Maria ^{[4
]}

Ikeda, Keigo ^{[6
]}

Milanesi, Ornella ^{[5
]}

Cimaz, Rolando ^{[7
]}

Ramoni, Veronique ^{[1
]}

Vignati, Gabriele ^{[8
,9
,10
]}

Martinelli, Stefano ^{[8
,9
,10
]}

Sadou, Youcef ^{[3
]}

Borghi, Adele ^{[2
]}

Tincani, Angela ^{[11
,12
,13
]}

Chan, Edward K. L. ^{[6
]}

Ruffatti, Amelia ^{[4
]}

机构：

[1] Osped Riuniti Bergamo, Dept Internal Med, I-24128 Bergamo, Italy

[2] Osped Riuniti Bergamo, Dept Pediat Cardiol, I-24128 Bergamo, Italy

[3] Osped Riuniti Bergamo, Neonatal Intens Care Unit, I-24128 Bergamo, Italy

[4] Univ Padua, Dept Rheumatol, Padua, Italy

[5] Univ Padua, Dept Pediat Cardiol, Padua, Italy

[6] Univ Florida, Dept Oral Biol, Gainesville, FL 32610 USA

[7] Meyer Hosp, Dept Pediat Rheumatol, Florence, Italy

[8] Osped Niguarda Ca Granda, Dept Obstet & Gynecol, Milan, Italy

[9] Osped Niguarda Ca Granda, Dept Pediat Cardiol, Milan, Italy

[10] Osped Niguarda Ca Granda, Neonatal Intens Care Unit, Milan, Italy

[11] Spedali Civil Brescia, Dept Rheumatol, I-25125 Brescia, Italy

[12] Spedali Civil Brescia, Dept Clin Immunol, I-25125 Brescia, Italy

[13] Univ Brescia, Brescia, Italy

来源：

JOURNAL OF RHEUMATOLOGY | 2009年 / 36卷 / 08期

基金：

美国国家卫生研究院;

关键词：

HEART BLOCK; ANTINUCLEAR ANTIBODIES; AUTOIMMUNE DISEASES; COMPLETE ATRIOVENTRICULAR-BLOCK; MULTICENTER EXPERIENCE;

D O I：

10.3899/jrheum.080737

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To study anti-Ro/La-negative congenital heart block (CHB). Methods. Forty-five fetuses with CHB were evaluated by analysis of anti-Ro/La antibodies using sensitive laboratory methods. Results. There were 9 cases of anti-Ro/La-negative CHB; 3 died (33.3%). Only 3 (33.3%) were complete in utero and 5 (55.5%) were unstable. No specific etiology was diagnosed. Six infants (66.6%) were given pacemakers. There were 36 cases of anti-Ro/La-positive CHB. All except 2 infants (94.4%) had complete atrioventricular block in utero. Ten died (27.8%), one (2.7%) developed severe dilated cardiomyopathy, and 26 (72.2%) were given pacemakers. Conclusion. Nine of the 45 consecutive CHB cases (20%) were anti-Ro/La-negative with no known cause. They were less stable and complete than the anti-Ro/La positive cases. (First Release July 1 2009; J Rheumatol 2009;36:1744-8: doi: 10.3899/jrheum.080737)

引用

页码：1744 / 1748

页数：5

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