A Dendritic Thioester Hydrogel Based on Thiol-Thioester Exchange as a Dissolvable Sealant System for Wound Closure

被引：189

作者：

Ghobril, Cynthia ^{[1
,2
]}

Charoen, Kristie ^{[1
,2
]}

Rodriguez, Edward K. ^{[3
]}

Nazarian, Ara ^{[3
]}

Grinstaff, Mark W. ^{[1
,2
]}

机构：

[1] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA

[2] Boston Univ, Dept Chem, Boston, MA 02215 USA

[3] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 52期

关键词：

dendrimers; hemostasis; hydrogels; supramolecular chemistry; wound dressing; BIOMEDICAL APPLICATIONS; DENDRIMERS; ADHESIVES; CHEMISTRY; MACROMERS; REPAIR;

D O I：

10.1002/anie.201308007

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Washable wound dressing: A dissolvable dendritic thioester hydrogel for wound closure has been developed. The hydrogel sealant adheres strongly to tissues, closes an ex vivo vein puncture, and withstands high pressures placed on a wound. This material can be washed off upon exposure to thiolates because a thiol-thioester exchange takes place, and gradual wound re-exposure may be achieved during surgical care. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：14070 / 14074

页数：5

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