Dendrimer therapeutics: covalent and ionic attachments

被引：51

作者：

El Kazzouli, Said ^{[1
]}

Mignani, Serge ^{[1
]}

Bousmina, Mosto ^{[1
,2
]}

Majoral, Jean-Pierre ^{[1
,3
]}

机构：

[1] Moroccan Adv Sci Innovat & Res MAScIR Fdn, Inst Nanomat & Nanotechnol INANOTECH, Rabat 10100, Morocco

[2] Hassan II Acad Sci & Technol, Rabat, Morocco

[3] CNRS, Lab Chim Coordinat, F-31077 Toulouse 4, France

来源：

NEW JOURNAL OF CHEMISTRY | 2012年 / 36卷 / 02期

关键词：

AMYLOID-INDUCED TOXICITY; TARGETED DRUG-DELIVERY; IN-VITRO; POLYMER THERAPEUTICS; CANCER; CONJUGATE; DESIGN; POLY(AMIDOAMINE); RELEASE; NANOMATERIALS;

D O I：

10.1039/c1nj20459a

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

This concise review focuses on dendrimers functionalized by different linkers required for covalent and ionic attachments of drugs to the dendrimer's surface and highlights the importance of the chemical nature of linkers for controlled release of free drugs. The stability of linkers under physiological conditions and their lability under acidic conditions such as those of endosomes and lysosomes or under enzymatic conditions will be discussed. Especially, we review functionality of the most recently reported drug-dendrimer conjugates. Then, we give a short comparison of dendrimer conjugates versus either dendrimer complexes or polymer therapeutics and finally we briefly summarize the importance of both targeted and nontargeted covalently conjugated drugs.

引用

页码：227 / 240

页数：14

共 93 条

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