Three generations of α,γ-diaminobutyric acid modified poly(propyleneimine) dendrimers and their cisplatin-type platinum complexes

被引：25

作者：

Bellis, E.

Hajba, L.

Kovacs, B.

Sandor, K.

Kollar, L.

Kokotos, G.

机构：

[1] Univ Pecs, Dept Inorgan Chem, H-7624 Pecs, Hungary

[2] Univ Athens, Organ Chem Lab, GR-15771 Athens, Greece

[3] Univ Veszprem, Dept Analyt Chem, H-8200 Veszprem, Hungary

[4] Univ Pecs, Dept Gen & Phys Chem, H-7624 Pecs, Hungary

[5] Hungarian Acad Sci, Res Grp Chem Sensors, H-7624 Pecs, Hungary

来源：

JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS | 2006年 / 69卷 / 1-2期

关键词：

dendrimer; cisplatin; platinum; infrared spectroscopy;

D O I：

10.1016/j.jbbm.2006.02.006

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Three generations of alpha,gamma-diaminobutyric acid modified poly(propyleneimine) dendrimers [DAB(AM)(n), n=4, 8, 16] containing 4, 8, 16 free amino groups were coupled with Boc-protected alpha,gamma-diaminobutyric acid (DABA) moieties in high yields. These modified dendrimers were deprotected and the chiral dendritic amines with 8, 16 and 32 amino groups on the surface were isolated in excellent yields. Dendrimers with cisplatin moieties at the periphery were obtained in the reaction of the free amine dendrimers and potassium tetrachloroplatinate(II). The highly insoluble complexes were isolated as hydrates and characterized by means of IR, TGA and elemental analysis. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：151 / 161

页数：11

共 32 条

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