Stereoselective synthesis of N-alkylaziridines from N-chloroamines

被引：8

作者：

Bew, Sean P. ^{[1
]}

Hughes, D. L.

Palmer, Nicholas J.

Savic, Vladimir

Soapi, Katy M.

Wilson, Martin A.

机构：

[1] Univ E Anglia, Sch Chem Sci, Norwich NR4 7TJ, Norfolk, England

[2] Biofocus Discovery Ltd, Saffron Walden CB10 1XL, Essex, England

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 41期

关键词：

D O I：

10.1039/b608504k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first racemic and stereoselective synthesis of cis- and trans-N-alkylaziridines via N-chloroamines; using this methodology an N-3,4,5-trimethoxybenzylaziridine was synthesised and efficiently cleaved, affording the corresponding NH aziridine in high yield.

引用

页码：4338 / 4340

页数：3

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