Dofetilide as Activator of Na/Ca Exchange: New Perspectives on an 'Old' Drug Editorial to: "Dofetilide Enhances the Contractility of Rat Ventricular Myocytes via Augmentation of Na+-Ca2+ Exchange" by Xuan-Ping Zhang et al.

被引:2
作者
Antoons, Gudrun [1 ,2 ]
Sipido, Karin R. [1 ,2 ]
机构
[1] Katholieke Univ Leuven, Lab Expt Cardiol, B-3000 Louvain, Belgium
[2] Katholieke Univ Leuven, Div Expt Cardiol, Dept Cardiovasc Med, B-3000 Louvain, Belgium
关键词
Dofetilide; Cardiac myocyte; Na/Ca exchange; Arrhythmias; Heart failure; III ANTIARRHYTHMIC ACTION; ATRIAL-FIBRILLATION; HEART-FAILURE; SARCOPLASMIC-RETICULUM; POSITIVE INOTROPY; CARDIAC MYOCYTES; CA2+ RELEASE; GUINEA-PIG; AGENT; BLOCK;
D O I
10.1007/s10557-009-6170-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:189 / 192
页数:4
相关论文
共 28 条
[11]   The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease [J].
Hobai, IA ;
O'Rourke, B .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2004, 13 (06) :653-664
[12]   The role of antiarrhythmic drug therapy for the prevention of sudden cardiac death [J].
Kamath, Ganesh S. ;
Mittal, Suneet .
PROGRESS IN CARDIOVASCULAR DISEASES, 2008, 50 (06) :439-448
[13]   DIFFERENTIAL-EFFECTS OF THE NEW CLASS-III AGENT DOFETILIDE ON POTASSIUM CURRENTS IN GUINEA-PIG CARDIOMYOCYTES [J].
KIEHN, J ;
VILLENA, P ;
BEYER, T ;
BRACHMANN, J .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1994, 24 (04) :566-572
[14]   Pharmacological treatment of atrial fibrillation: Mechanisms of action and efficacy of class III drugs [J].
Lombardi, Federico ;
Terranova, Paolo .
CURRENT MEDICINAL CHEMISTRY, 2006, 13 (14) :1635-1653
[15]   Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage [J].
Molinaro, Pasquale ;
Cuomo, Ornella ;
Pignataro, Giuseppe ;
Boscia, Francesca ;
Sirabella, Rossana ;
Pannaccione, Anna ;
Secondo, Agnese ;
Scorziello, Antonella ;
Adornetto, Annagrazia ;
Gala, Rosaria ;
Viggiano, Davide ;
Sokolow, Sophie ;
Herchuelz, Andre ;
Schurmans, Stephane ;
Di Renzo, Gianfranco ;
Annunziato, Lucio .
JOURNAL OF NEUROSCIENCE, 2008, 28 (05) :1179-1184
[16]   POSITIVE INOTROPY LINKED WITH CLASS-III ANTIARRHYTHMIC ACTION - ELECTROPHYSIOLOGICAL EFFECTS OF THE CARDIOTONIC AGENT DPI 201-106 IN THE DOG HEART INVIVO [J].
MORTENSEN, E ;
TANDE, PM ;
KLOW, NE ;
PLATOU, ES ;
REFSUM, H .
CARDIOVASCULAR RESEARCH, 1990, 24 (11) :911-917
[17]   Pharmacological inhibition of Na/Ca exchange results in increased cellular Ca2+ load attributable to the predominance of forward mode block [J].
Ozdemir, Semir ;
Bito, Virginie ;
Holemans, Patricia ;
Vinet, Laurent ;
Mercadier, Jean-Jacques ;
Varro, Andras ;
Sipido, Karin R. .
CIRCULATION RESEARCH, 2008, 102 (11) :1398-1405
[18]   Efficacy of dofetilide in the treatment of atrial fibrillation-flutter in patients with reduced left ventricular function - A Danish Investigations of Arrhythmia and Mortality ON Dofetilide (DIAMOND) substudy [J].
Pedersen, OD ;
Bagger, H ;
Keller, N ;
Marchant, B ;
Kober, L ;
Torp-Pedersen, C .
CIRCULATION, 2001, 104 (03) :292-296
[19]   Arrhythmogenesis and contractile dysfunction in heart failure -: Roles of sodium-calcium exchange, inward rectifier potassium current, and residual β-adrenergic responsiveness [J].
Pogwizd, SM ;
Schlotthauer, K ;
Li, L ;
Yuan, WL ;
Bers, DM .
CIRCULATION RESEARCH, 2001, 88 (11) :1159-1167
[20]   Impaired contractile performance of cultured rabbit ventricular myocytes after adenoviral gene transfer of Na+-Ca2+ exchanger [J].
Schillinger, W ;
Janssen, PML ;
Emami, S ;
Henderson, SA ;
Ross, RS ;
Teucher, N ;
Zeitz, O ;
Philipson, KD ;
Prestle, J ;
Hasenfuss, G .
CIRCULATION RESEARCH, 2000, 87 (07) :581-587