Augmenter of liver regeneration (ALR) may promote liver regeneration by reducing natural killer (NK) cell activity in human liver diseases

被引：122

作者：

Tanigawa, K ^{[1
]}

Sakaida, I ^{[1
]}

Masuhara, M ^{[1
]}

Hagiya, M ^{[1
]}

Okita, K ^{[1
]}

机构：

[1] Yamaguchi Univ, Sch Med, Dept Internal Med 1, Ube, Yamaguchi 7558505, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2000年 / 35卷 / 02期

关键词：

augmenter of liver regeneration (ALR); liver regeneration; NK cell activity;

D O I：

10.1007/s005350050023

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Cytotoxicity of liver natural killer cells against regenerating hepatocytes has been reported as a possible mechanism of regeneration failure in fulminant hepatitis. An augmenter of liver regeneration (ALR) inhibits liver natural killer cell activity in rats. In this study, we measured hepatic expression of ALR mRNA, blood levels of ALR, and peripheral blood natural killer cell activity in patients with various types of acute liver disease to investigate the relationship between failure of liver regeneration and hepatic natural killer cells. Hepatic ALR mRNA expression was higher in liver disease patients than in non-liver disease controls, and a correlation was found between serum ALR values and hepatic levels of ALR mRNA. In acute liver injury? the serum ALR level also showed a negative correlation with NK activity. ALR was produced by and released from the liver at the time of hepatic injury. Our findings suggest that ALR may protect against failure of regeneration by inhibition of hepatic natural killer cell activity in acute liver injury.

引用

页码：112 / 119

页数：8

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