Hydroxamic acids - An intriguing family of enzyme inhibitors and biomedical ligands

被引：167

作者：

Marmion, CJ ^{[1
]}

Griffith, D ^{[1
]}

Nolan, KB ^{[1
]}

机构：

[1] Royal Coll Surgeons Ireland, Dept Pharmaceut & Med Chem, Ctr Synth & Chem Biol, Dublin 2, Ireland

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2004年 / 15期

关键词：

hydroxamic acids; chelates; siderophores; enzyme inhibitors; nitric oxide donors; cyclooxygenase;

D O I：

10.1002/ejic.200400221

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This review on hydroxamic acids deals with their efficacy as inhibitors of enzymes including cyclooxygenases, their synthesis, the complexity and structural diversity of their metal complexes, and their ability to act as effective nitric oxide donors. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).

引用

收藏

页码：3003 / 3016

页数：14

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