A convenient method for the preparation of α-ketoacetals

被引：14

作者：

Adamczyk, M ^{[1
]}

Johnson, DD ^{[1
]}

Mattingly, PG ^{[1
]}

Pan, Y ^{[1
]}

Reddy, RE ^{[1
]}

机构：

[1] Abbott Labs, Dept Chem, Div Diagnost, Abbott Pk, IL 60064 USA

来源：

SYNTHETIC COMMUNICATIONS | 2002年 / 32卷 / 20期

关键词：

alpha-ketoacetals; imidazo[1,2-a]pyrazin-3(7H)-one; Grignard reaction; ethyl diethoxyacetate;

D O I：

10.1081/SCC-120013744

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for the preparation of alpha-ketoacetal derivatives 2a-g was developed by addition of Grignard reagent (1a-g) to commercially available ethyl diethoxyacetate (3) in 60-96% yield.

引用

页码：3199 / 3205

页数：7

共 32 条

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