CD8 expression in a case of chronic lymphocytic leukemia with trisomy 12

被引：4

作者：

Hanza, MCB

Palacios, MF

Dourisboure, R

Slavutsky, I

Chena, C

Galmarini, C

Sarmiento, M

de Bracco, MME

Scolnik, M

机构：

[1] Acad Nacl Med, IO, IIHEMA,Dept Immunol Oncol, Inst Invest Hematol Mariano R Castex, RA-1425 Buenos Aires, DF, Argentina

[2] Acad Nacl Med, Inst Invest Hematol Mariano R Castex, Dept Genet, RA-1425 Buenos Aires, DF, Argentina

[3] Acad Nacl Med, Inst Invest Hematol Mariano R Castex, Dept Clin Hematol, RA-1425 Buenos Aires, DF, Argentina

来源：

ACTA HAEMATOLOGICA | 1999年 / 102卷 / 04期

关键词：

atypical lymphocytes; CD8; chronic lymphocytic leukemia; trisomy; 12;

D O I：

10.1159/000041013

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

We report a case of B-cell chronic lymphocytic leukemia (B-CLL) with aberrant expression of the T-cell-associated antigen CD8, as revealed by two-color flow-cytometric analysis. DNA studies showed immunoglobulin heavy-chain gene rearrangement, bur not of gamma-chain T-cell receptor, confirming the B-cell origin of the neoplastic cells. Ploidy analysis showed a tetraploid population and high S-phase fraction. B-CLL cells also carried trisomy 12, detected by fluorescence in situ hybridization. The identification of more cases with the same features would be necessary to establish the prognosis of this subtype of B-CLL. Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：190 / 195

页数：6

共 26 条

[1]

Attadia V, 1996, LEUKEMIA, V10, P1544

[2]

Brunet C, 1998, HEMATOL CELL THER, V40, P279

[3]

TRISOMY-12 IS UNCOMMON IN TYPICAL CHRONIC LYMPHOCYTIC LEUKEMIAS [J].

CRIEL, A ;

WLODARSKA, I ;

MEEUS, P ;

STUL, M ;

LOUWAGIE, A ;

VANHOOF, A ;

HIDAJAT, M ;

MECUCCI, C ;

VANDENBERGHE, H .

BRITISH JOURNAL OF HAEMATOLOGY, 1994, 87 (03) :523-528

[4]

The concept of typical and atypical chronic lymphocytic leukaemia [J].

Criel, A ;

Michaux, L ;

De Wolf-Peeters, C .

LEUKEMIA & LYMPHOMA, 1999, 33 (1-2) :33-+

[5]

NONRADIOACTIVE INSITU HYBRIDIZATION FOR THE DETECTION AND MONITORING OF TRISOMY-12 IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA [J].

CUNEO, A ;

WLODARSKA, I ;

ALY, MS ;

PIVA, N ;

CARLI, MG ;

FAGIOLI, F ;

TALLARICO, A ;

PAZZI, I ;

FERRARI, L ;

CASSIMAN, JJ ;

VANDENBERGHE, H ;

CASTOLDI, GL .

BRITISH JOURNAL OF HAEMATOLOGY, 1992, 81 (02) :192-196

[6]

APPEARANCE OF THE T-CELL MARKER CD8 ON B-CHRONIC LYMPHATIC-LEUKEMIA CELLS IN LONG-TERM CULTURES [J].

FARKAS, R ;

BENEFRAIM, S ;

MANOR, Y ;

ZANBAR, I ;

KLAJMAN, A .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 1991, 34 (03) :181-185

[7]

GarciaMarco JA, 1996, LEUKEMIA, V10, P1705

[8]

ABERRANT CD8 ANTIGEN EXPRESSION IN A PATIENT WITH B-CHRONIC LYMPHOCYTIC-LEUKEMIA SHOWING UNUSUAL DISEASE PROGRESSION [J].

GHOSH, K ;

SIVAKUMARAN, M ;

WOOD, JK .

BRITISH JOURNAL OF HAEMATOLOGY, 1993, 85 (01) :205-206

[9]

Hernandez JM, 1995, LEUKEMIA, V9, P2140

[10]

PROGNOSTIC SUBGROUPS IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA DEFINED BY SPECIFIC CHROMOSOMAL-ABNORMALITIES [J].

JULIUSSON, G ;

OSCIER, DG ;

FITCHETT, M ;

ROSS, FM ;

STOCKDILL, G ;

MACKIE, MJ ;

PARKER, AC ;

CASTOLDI, GL ;

CUNEO, A ;

KNUUTILA, S ;

ELONEN, E ;

GAHRTON, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (11) :720-724

← 1 2 3 →