Fine particulate air pollution and systemic autoimmune rheumatic disease in two Canadian provinces

被引:90
作者
Bernatsky, Sasha [1 ,2 ]
Smargiassi, Audrey [3 ,4 ]
Barnabe, Cheryl [5 ,6 ]
Svenson, Lawrence W. [6 ,13 ,14 ,15 ]
Brand, Allan [3 ]
Martin, Randall V. [7 ,8 ]
Hudson, Marie [9 ,10 ]
Clarke, Ann E. [1 ,11 ]
Fortin, Paul R. [12 ]
van Donkelaar, Aaron [7 ]
Edworthy, Steven [5 ,6 ]
Belisle, Patrick [2 ]
Joseph, Lawrence [1 ,2 ]
机构
[1] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Purvis Hall 1020 Pine Ave West, Montreal, PQ H3A 1A2, Canada
[2] McGill Univ, Royal Victoria Hosp, Ctr Hlth, Div Clin Epidemiol, V Pavil 687,Pine Ave West, Montreal, PQ H3A 1A1, Canada
[3] Univ Montreal, Ecole Sante Publ, Dept Sante Environm & Sante Travail, Pavillon Marguerite dYouville,CP 6128, Montreal, PQ, Canada
[4] Inst Natl Sante Publ Quebec, 190 Cremazie Blvd E, Montreal, PQ H2P 1E2, Canada
[5] Univ Calgary, Dept Med, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada
[6] Univ Calgary, Dept Community Hlth Sci, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada
[7] Dalhousie Univ, Dept Phys & Atmospher Sci, 6310 Coburg Rd POB 15000, Halifax, NS B3H 4R2, Canada
[8] Harvard Smithsonian Ctr Astrophys, 60 Garden St, Cambridge, MA 02138 USA
[9] McGill Univ, Dept Med, 1001 Decarie Blvd,Mail Drop D05-2214, Montreal, PQ H4A 3J1, Canada
[10] McGill Univ, Jewish Gen Hosp, Div Rheumatol, 3755 Cote Ste Catherine Rd, Montreal, PQ H3T 1E2, Canada
[11] McGill Univ, Ctr Hlth, Div Allergy & Clin Immunol, 1547 Ave Pins, Montreal, PQ H3G 1B3, Canada
[12] Univ Laval, Div Rheumatol, Dept Med, Bur 4633, Pavilion Ferdinand Vandry 1050,Ave Med, Quebec City, PQ G1V 0A6, Canada
[13] Alberta Minist Hlth, Surveillance & Assessment Branch, 10025 Jasper Ave, Edmonton, AB T5J 1S6, Canada
[14] Univ Alberta, Canada Sch Publ Hlth, 11405 87 Ave NW, Edmonton, AB T6G 1C9, Canada
[15] Univ Calgary, Canada Dept Community Hlth Sci, 2500 Hosp Dr NW, Calgary, AB T2N 1N4, Canada
基金
加拿大健康研究院;
关键词
Systemic lupus erythematosus (SLE); Autoimmune diseases; Environmental factors; LUPUS-ERYTHEMATOSUS; DNA-DAMAGE; MATTER; EXPOSURE; RISK; ASSOCIATIONS; POPULATION; PREVALENCE; PARTICLES; HUMANS;
D O I
10.1016/j.envres.2015.12.021
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Objective: To estimate the degree to which fine particulate (PM2.5) air pollution is associated with systemic autoimmune rheumatic diseases (SARDs). Methods: We used population-based administrative data from Alberta (1993-2007) and Quebec (19892011). SARD algorithms included >= 2 physician billing codes, or >= 1 rheumatology billing code, or 1 hospitalization diagnostic code (for systemic lupus, Sjogren's Syndrome, scleroderma, polymyositis, dermatomyositis, or undifferentiated connective tissue disease). Bayesian hierarchical latent class regression models estimated the probability that any given resident was a SARD case, based on the algorithms. Mean 2001-2006 residential ambient PM2.5 levels were assigned using satellite-derived data for dissemination area regions in Alberta and CLSC regions in Quebec. The sum of individual level probabilities provided the estimated total cases per region in each province, according to age, sex, urban-versus-rural residence, income, and PM2.5 levels. In Alberta, we ran separate models for First-Nations (FN) and non-First Nations subgroups. Bayesian logistic regression modeling generated odds ratio (OR) estimates for being a SARD case, accounting concurrently for demographics, as well as an interaction term between age and sex. Results: Our data suggested that the probability of being a SARD case was higher among females versus males and for residents aged >45 versus younger, with the highest ORs for older females. Independently, the odds of being a SARDs case increased with PM2.5 levels in both provinces. Conclusion: Our data suggest that PM2.5 exposure may be associated with an increased risk of SARDs. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:85 / 91
页数:7
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