Cytotoxic prenylxanthones from Garcinia bracteata

被引：87

作者：

Thoison, O

Fahy, J

Dumontet, V

Chiaroni, A

Riche, C

Van Tri, M

Sévenet, T ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] Ctr Rech Pierre Fabre, Div Chim Med 5, F-81106 Castres, France

[3] NCST, Inst Chem, Hanoi, Vietnam

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 04期

关键词：

D O I：

10.1021/np9903088

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of a leaf extract of G. bracteata has yielded six new prenylxanthones, bractatin(1), isobractatin (2), 1-O-methylbractatin (3), 1-O-methylisobractatin (4), 1-O-methyl-8-methoxy-8,8a-dihydrobractatin (5), and 1-O-methylneobractatin (6). The structures of these compounds have been elucidated by spectroscopic means (NMR, MS), literature data, and X-ray crystallographic analysis of 2. These compounds possess significant cytotoxicity against the KB cell line.

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页码：441 / 446

页数：6

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