Signaling through gp130: Toward a general scenario of cytokine action

被引：27

作者：

Fukada, T ^{[1
]}

Yoshida, Y ^{[1
]}

Nishida, K ^{[1
]}

Ohtani, T ^{[1
]}

Shirogane, T ^{[1
]}

Hibi, M ^{[1
]}

Hirano, T ^{[1
]}

机构：

[1] Osaka Univ, Div Mol Oncol C7, Biomed Res Ctr, Grad Sch Med, Suita, Osaka 5650871, Japan

来源：

GROWTH FACTORS | 1999年 / 17卷 / 02期

关键词：

interleukin-6; cytokine; gp130; JAK; STAT; SHP-2; Gab-family;

D O I：

10.3109/08977199909103518

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cytokines play roles in a wide range of responses such as immune response, hematopoiesis and inflammation. A large volume of studies revealed that cytokines show functional pleiotropy and redundancy. Gp130 is a receptor subunit shared by the interleukin-6 family of cytokines, We describe and discuss signaling through gp130 in relation to a general scenario for cytokine signaling regulating cell growth, differentiation and survival.

引用

页码：81 / 91

页数：11

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