Signaling through gp130: Toward a general scenario of cytokine action

被引:27
作者
Fukada, T [1 ]
Yoshida, Y [1 ]
Nishida, K [1 ]
Ohtani, T [1 ]
Shirogane, T [1 ]
Hibi, M [1 ]
Hirano, T [1 ]
机构
[1] Osaka Univ, Div Mol Oncol C7, Biomed Res Ctr, Grad Sch Med, Suita, Osaka 5650871, Japan
关键词
interleukin-6; cytokine; gp130; JAK; STAT; SHP-2; Gab-family;
D O I
10.3109/08977199909103518
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cytokines play roles in a wide range of responses such as immune response, hematopoiesis and inflammation. A large volume of studies revealed that cytokines show functional pleiotropy and redundancy. Gp130 is a receptor subunit shared by the interleukin-6 family of cytokines, We describe and discuss signaling through gp130 in relation to a general scenario for cytokine signaling regulating cell growth, differentiation and survival.
引用
收藏
页码:81 / 91
页数:11
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