Asymmetric electrophilic α-amination of carbonyl groups

被引：171

作者：

Greck, C ^{[1
]}

Drouillat, B ^{[1
]}

Thomassigny, C ^{[1
]}

机构：

[1] Univ Versailles, CNRS, UMR 8086, Lab SIR COB, F-78035 Versailles, France

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 2004卷 / 07期

关键词：

amino acids; asymmetric synthesis; azodicarboxylate; chiral catalysts; electrophilic amination; stereoselectivity;

D O I：

10.1002/ejoc.200300657

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The electrophilic amination constitutes an unconventional C-N bond-forming reaction. Asymmetric versions have been developed using chiral reagents or catalysts and starting from optically pure substrates. The aminated products can be obtained with high stereoselectivities. These methodologies are flexible routes for the synthesis of a-amino acids and nitrogen heterocycles. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

引用

页码：1377 / 1385

页数：9

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