Signal transduction - Inositol lipid pathways turn turtle

被引：47

作者：

Hinchliffe, K

Irvine, R

机构：

[1] University of Cambridge,the Department of Pharmacology

来源：

NATURE | 1997年 / 390卷 / 6656期

关键词：

D O I：

10.1038/36458

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phospholipids are important components of cellular signalling pathways and of cell membranes. Two papers in this issue now suggest that phosphatidylinositol-4,5-bisphosphate, a key player in phospholipid synthesis, can be produced by an alternative pathway that involves an enzyme identified nearly a decade ago and a novel lipid substrate. Another newly discovered inositol lipid in this pathway, phosphatidylinositol-3,5-bisphosphate, appears to be involved in the response to osmotic stress in yeast and in mammalian cells.

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页码：123 / 124

页数：2

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